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Overview

Uniprot ID	A0A286ZVG0
Protein Name	Prosaposin
Gene Name	PSAP
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
453	TARVTPLKDGGFCEV
536	GACPSAHKPLLGTEK

Function

Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling

Protein Sequence

10 MMTSSSQPCD 20 ICDTAAFWLC 30 GLGSHSWQGA 40 RLVSRGMAGL 50 PDPGETNEAS 60 LVCGVLTLVF 70 LAALASPVLG 80 LRECTRGSAV 90 WCQNVKTASD 100 CGALQHCLQT 110 VWNKPTVKSL 120 PCDICKDVIT 130 AAGDMLKDNA 140 TEQEILVYLE 150 RTCDWLPKPN 160 MSATCKEIVD 170 SYFPVILDMI 180 KGQMSKPGEV 190 CSALNLCESL 200 QKHLAELTQQ 210 KQLESNQIPE 220 LDLAEAVAPF 230 MANIPLLLYP 240 QDGSSSKPRP 250 KADGDVCQDC 260 IQMVTDLQNA 270 VRTNSTFVEA 280 LVNHAKEECD 290 RLGPGMADMC 300 KNYISQYSEI 310 AIQMMMHMQP 320 KDICGLVGFC 330 EEVKEVPMQT 340 LVPAKVLSEK 350 VISALELVEP 360 IKKDLVPEKA 370 TIYCEVCEFV 380 VKEVAKLIDN 390 NRTEEEIIHA 400 LDKVCSKLPT 410 SMSEECQELV 420 DTYGSSILSL 430 LLQEASPELV 440 CSMLHLCSTQ 450 GLPVLTARVT 460 PLKDGGFCEV 470 CKRLVSYLDR 480 NLEKNSTKQE 490 ILAALEKGCS 500 FLPDPYQKQC 510 DQFVTEYEPV 520 LVEILVEVME 530 PSFVCSKIGA 540 CPSAHKPLLG 550 TEKCVWGPSF 560 WCQNMESAAL 570 CNAVEHCKRH VWN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0016020	membrane
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0008289	lipid binding
Biological Process	GO:0006665	sphingolipid metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.