Overview
| Uniprot ID | A0A286ZVG1 |
|---|
| Protein Name | Serine/threonine-protein phosphatase PGAM5, mitochondrial |
|---|
| Gene Name | PGAM5 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 162 |
ETTDIISKHLPGVCR |
Function
Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy. Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1. Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation. Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3. Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2. Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria
Protein Sequence
10
MAFRQALQLA
20
ACGLAGGSAA
30
VLFSAVAVGK
40
PRAGGDAEPR
50
VVEPPAWAGA
60
ARPGPGVWDP
70
NWDRREPLSL
80
VNLRKRNLEP
90
GEEELASRLD
100
HYKAKATRHI
110
FLIRHSQYHV
120
DASLEKDRTL
130
TPLGREQAEL
140
TGLRLASLGL
150
KFNKIVHSSM
160
TRAIETTDII
170
SKHLPGVCRV
180
STDLLREGAP
190
IEPDPPVSHW
200
KPEAVYYEDG
210
ARIEAAFRNY
220
IHRADAKQQE
230
DSYEIFICHA
240
NVIRYIVCRA
250
LQFPPEGWLR
260
LSLNNGSITH
270
LVVRPDGRVA
280
LRALGDTGFM
PPDKISRS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Biological Process |
GO:0070266 |
necroptotic process |
| Biological Process |
GO:0120163 |
negative regulation of cold-induced thermogenesis |
| Biological Process |
GO:0090141 |
positive regulation of mitochondrial fission |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.