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Overview

Uniprot ID	A0A286ZVX4
Protein Name	Unconventional myosin-XVIIIa
Gene Name	MYO18A
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1005	RRATSMRKTFTTGVA
1015	TTGVAAVKKKSLCIQ
1427	QRALQQLKKKCQRLT

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity

Protein Sequence

10 MFNLMKKDKD 20 RDGGRKEKKE 30 KKEKKERMSA 40 AELRSLEEMG 50 LRRGFFNLNR 60 SSKRDSKTRL 70 EISNPIPIKV 80 ASGSDLHLTD 90 IDSDSNRGSV 100 ILDSGHLSTA 110 SSSDDLKGEE 120 GSLRGSVLQR 130 AAKFGSLAKQ 140 NSQMIVKRFS 150 FSQRSRDESA 160 SETSTPSEHS 170 AAPSPQVEVR 180 TLEGQLTQHP 190 GPGIPRPGPR 200 SRVPELVTKR 210 FPADLRLPPV 220 MPPPPPALRE 230 LELQRRPTGD 240 FGFSLRRTTM 250 LDRGPEGQAY 260 RRVVHFAEPG 270 AGTKDLALGL 280 VPGDRLVEIN 290 GHNVESKSRD 300 EIVEMIRQSG 310 DSVRLKVQPI 320 PELSELSRSW 330 LRSGEGPRRE 340 PAHVKTEEQI 350 AAEEAWCETE 360 KVWLVHKDGF 370 SLASQLKSEE 380 LSLPEGKVRV 390 KLDHDGTILD 400 VDEDDVEKAN 410 APPCDRLEDL 420 ASLVYLNESS 430 VLHTLRQRYG 440 ASLLHTYAGP 450 SLLVLSPRGA 460 PAVYSEKVMH 470 MFKGCRREDM 480 APHIYAVAQT 490 AYRAMLMSRQ 500 DQSIILLGSS 510 GSGKTTSCQH 520 LVQYLATIAG 530 TSGNKVFSVD 540 KWQALYTLLE 550 AFGNSPTIMN 560 GNATRFSQIL 570 SLDFDQAGQV 580 ASASIQTMLL 590 EKLRVARRPA 600 GEATFNIFYY 610 LLACGDGTLR 620 TELHLNHLAE 630 NNVFGIVPLA 640 KPEEKQKAAQ 650 QFSKLQTAMR 660 VLGISPDEQK 670 ACWLILAAIY 680 HLGAAGATKP 690 ATAGRRQFAR 700 HEWAQKAAYL 710 LGCSLEELSS 720 AIFKHQLQAS 730 TLQRSTSFRQ 740 GPEESSLGDS 750 TGPKLSALEC 760 LEGMASGLYS 770 ELFTLLISLV 780 NRALKSSQHS 790 LCSMMIVDTP 800 GFQNPEQGGS 810 ARGASFEELC 820 HNYAQDRLQR 830 LFHERTFVQE 840 LERYKEENIE 850 VAFDDLEPAT 860 DDSVAAVDQA 870 CHQSLVRSLA 880 RTDERGLLWL 890 LEEEALVPGA 900 TEDALLERLF 910 SYYGPREGDK 920 KGQSPLLRSS 930 KPHHFLLGHS 940 HGTNWVEYNA 950 AGWLSYTKQN 960 PATQNAPRLL 970 QDSQKKIISN 980 LFLGRAGSAT 990 VLSGSIAGLE 1000 GGSQLALRRA 1010 TSMRKTFTTG 1020 VAAVKKKSLC 1030 IQIKLQVDAL 1040 IDTIKKSKLH 1050 FVHCFLPVAE 1060 GWAGEPRSAS 1070 SRRVSSSSEL 1080 DLPPGEHCDA 1090 GLLPLDVPLL 1100 RTQLRGSRLL 1110 DAMRMYRQGY 1120 PDHMVFAEFR 1130 RRFDVLAPHL 1140 TKKHGRNYIV 1150 VDERRAVEEL 1160 LESLDLEKSS 1170 CCMGLSRVFF 1180 RAGTLARLEE 1190 QRDEQTSRNL 1200 TLFQAACRGY 1210 LARQLFKKKK 1220 IQDLAIRCVQ 1230 KNIKKNKGVK 1240 DWPWWKLFTT 1250 VRPLIEVQLS 1260 EEQIRNRDEE 1270 IQQLRSKLEK 1280 VEKERNELRL 1290 SSDRLETRIS 1300 ELTSELTDER 1310 NTGESASQLL 1320 DAETAERLRA 1330 EKEMKELQTQ 1340 YDALKKKMEV 1350 MEMEVMEARL 1360 IRAAEVNGEV 1370 DDEDTGGEWR 1380 LKYERAVREV 1390 DFTKKRLQQE 1400 FEDKLEVEQQ 1410 NKRQLERRLG 1420 DLQADSDESQ 1430 RALQQLKKKC 1440 QRLTAELQDT 1450 KLHLEGQQVR 1460 NHELEKKQRR 1470 FDSELSQAHE 1480 EAQREKLQRE 1490 KLQREKDTLL 1500 AEAFSLKQQL 1510 EEKDMDIAGF 1520 TQKVVSLEAE 1530 LQDISSQESK 1540 DEASLAKVKK 1550 QLRDLEAKVK 1560 DQEEELDEQA 1570 GTIQMLEQAK 1580 LRLEMEMERM 1590 RQTHSKEMES 1600 RDEEVEEARQ 1610 SCQKKLKQME 1620 VQLEEEYEDK 1630 QKVLREKREL 1640 ESKLATLSDQ 1650 VNQRDFESEK 1660 RLRKDLKRTK 1670 ALLADAQIML 1680 DHLKNNVPSK 1690 REIAQLKNQL 1700 EESEFTCAAA 1710 VKARKAMEVE 1720 IEDLHLQIDD 1730 IAKAKTALEE 1740 QLSRLQREKN 1750 EIQNRLEEDQ 1760 EDMNELMKKH 1770 KAAVAQASRD 1780 LAQMNDLQAQ 1790 LEEANKEKQE 1800 LQEKLQALQS 1810 QVEFLEQSMV 1820 DKSLVSRQEA 1830 KIRELETRLE 1840 FERTQVKRLE 1850 SLASRLKENM 1860 EKLTEERDQR 1870 TAAENREKEQ 1880 NKRLQRQLRD 1890 TKEEMGELAR 1900 KEAEASRKKH 1910 ELEMDLESLE 1920 AANQSLQADL 1930 KLAFKRIGDL 1940 QAAIEDEMES 1950 DENEDLINSE 1960 GDSDVDSELE 1970 DRVDGVKSWL 1980 SKNKGPSKAA 1990 SDDGSLKSSS 2000 PTSYWKSLAP 2010 DRSDDEHDPL 2020 DSTSRPRYTH 2030 NYLSDSDTEA KQTETNA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005815	microtubule organizing center
Cellular Component	GO:0016459	myosin complex
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA
Molecular Function	GO:0003774	cytoskeletal motor activity
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006259	DNA metabolic process
Biological Process	GO:1903028	positive regulation of opsonization
Biological Process	GO:0043030	regulation of macrophage activation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.