Overview
| Uniprot ID | A0A286ZWI2 |
|---|
| Protein Name | Cleavage and polyadenylation specificity factor subunit 5 |
|---|
| Gene Name | NUDT21 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 167 |
YIPAHITKPKEHKKL |
| 173 |
TKPKEHKKLFLVQLQ |
| 23 |
GVNQYGNKYIQQTKP |
| 29 |
NKYIQQTKPLTLERT |
| 56 |
TKEPLYEKDSSVAAR |
Function
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs
Protein Sequence
10
MSVVPPNRSQ
20
TGWPRGVNQY
30
GNKYIQQTKP
40
LTLERTINLY
50
PLTNYTFGTK
60
EPLYEKDSSV
70
AARFQRMREE
80
FDKIGMRRTV
90
EGVLIVHEHR
100
LPHVLLLQLG
110
TTFFKLPGGE
120
LNPGEDEVEG
130
LKRLMTEILG
140
RQDGVLQDWV
150
IDDCIGNWWR
160
PNFEPPQYPY
170
IPAHITKPKE
180
HKKLFLVQLQ
190
EKALFAVPKN
200
YKLVAAPLFE
210
LYDNAPGYGP
220
IISSLPQLLS
RFNFIYN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005849 |
mRNA cleavage factor complex |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Biological Process |
GO:0031124 |
mRNA 3'-end processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.