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Overview

Uniprot IDA0A286ZWL1
Protein NameLeiomodin-1
Gene NameLMOD1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
439 MEMAKLLKENTTLLK

Function

Required for proper contractility of visceral smooth muscle cells. Mediates nucleation of actin filaments

Protein Sequence

10 MSKVAKYRRQ 20 VSEDPDIDSL 30 LSTLSPEEME 40 ELEKELDVAD 50 PDGSVPLGLR 60 QRNQTEKPST 70 GTYNREAMLN 80 FCEKETKKLI 90 QREMSVDEGK 100 QGETKADAKN 110 GEERCRDASK 120 KPLGPRRDSD 130 LAKEPRKGVL 140 KKSFSRDKEE 150 ADGKSTERPK 160 EEKLIRGLEK 170 GRVRAAVDRK 180 EAGKEGRAQE 190 GTAAPRKDEE 200 RQGRDRSPGA 210 SRDKGKKGEE 220 KKEASRREEV 230 AKVKGRGKDA 240 DARTEGQEVA 250 RGTDARTERQ 260 EVKRRSGDTG 270 ARTEEEKAKK 280 EEPPHAKAPR 290 EESKTPAPEP 300 PAPGAPPKPA 310 DVPAQAGEEA 320 APSIFDEPLE 330 RVRNNDPEVT 340 EVNVNNSDCI 350 TTEILVRFAE 360 ALEFNTAVKV 370 FALANTRADD 380 HVAFAIAIML 390 KANKTITSLN 400 LDSNHITSKG 410 ILAIFRALLQ 420 NSSLTELRFH 430 NQRHICGGKT 440 EMEMAKLLKE 450 NTTLLKLGYH 460 FELAGPRMTV 470 TNLLSRNMDR 480 QRQKRLQEQR 490 QAQEARGEKA 500 LLQVPKAGAP 510 AKGSPKPSPQ 520 PSPKAAPKNS 530 PGKGGAPAAP 540 PPPPPPLAPP 550 LIMENLKNSL 560 SPATQRKMGD 570 RLLPAQEKNS 580 RDQLLAAIRS 590 SNLKQLKKVQ VPKLLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0030016 myofibril
Cellular Component GO:0005865 striated muscle thin filament
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005523 tropomyosin binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0045010 actin nucleation
Biological Process GO:0006936 muscle contraction
Biological Process GO:0030239 myofibril assembly
Biological Process GO:0051694 pointed-end actin filament capping
Biological Process GO:0030838 positive regulation of actin filament polymerization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.