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Overview

Uniprot ID	A0A286ZWX4
Protein Name	Acyl-coenzyme A oxidase
Gene Name	ACOX1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
227	EAARCLSKACTIAIR

Function

Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2))

Protein Sequence

10 MAASVQTTGD 20 HWHLRPDGAG 30 PRFVQRGHPG 40 PLDLHVGMFL 50 PTLLHQATEE 60 QQERFFMPAW 70 NFKIIGTYAQ 80 TEMGHGTHLR 90 GLETTATYDP 100 ATEEFILNSP 110 TVTSIKWWPG 120 GLGKTSNHAI 130 VLAQLITQGK 140 CYGLHAFIVP 150 IREQGTHKPL 160 PGITVGDIGP 170 KFGYDEMDNG 180 YLKMDNYRIP 190 RENMLMKYAQ 200 VKPDGTYVKP 210 LSNKLTYGTM 220 VFIRSFLVGE 230 AARCLSKACT 240 IAIRYSAVRH 250 QSELRPDEPE 260 PQILDYQTQQ 270 YKLFPFLATA 280 YAFQFVGAYI 290 KETYHRINEN 300 IRQGDLSGLP 310 ELHALTAGLK 320 AFTSWTANAA 330 IEACRMACGG 340 HGYSHCSGLP 350 NIYVNFTPTC 360 TFEGENTVMM 370 LQTARFLMKS 380 YNQVHSGKLV 390 CGMVSYLNDL 400 PSQRIQPQQV 410 AAWPTVADIN 420 SPDSLIEAYR 430 LRASRLVEIA 440 AKNLQTEMSH 450 RKSKEAAWNL 460 TSIDLVRASE 470 AHCHYVVVKL 480 FAEKLHQIQE 490 RSIHAVLRNL 500 CLLYALYGIS 510 QNSGDFLQGS 520 IMTESQVTHV 530 NERVKELLMA 540 IRPEAVALVD 550 AFDFQDVTLG 560 SVLGRYDGNV 570 YENMFEWAKK 580 SPLNKTEVKS 590 KNSFSPFLKS FI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005777	peroxisome
Biological Process	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
Molecular Function	GO:0003997	acyl-CoA oxidase activity
Molecular Function	GO:0071949	FAD binding
Molecular Function	GO:0005504	fatty acid binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.