Search Results
Overview
| Uniprot ID | A0A286ZX26 |
|---|---|
| Protein Name | Cathepsin D |
| Gene Name | CTSD |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | IACWIHHKYNSGKSS |
| 127 | HHKYNSGKSSTYVKN |
| 346 | TLGGKKYKLSSENYT |
Function
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation
Protein Sequence
10
MQPPSLLLLA
20
LGLLAAPAAA
30
LIRIPLHKFT
40
SIRRTMSEVG
50
GPVENLIAKG
60
PISKYSQGVP
70
AVTQGPIPEV
80
LKNYMDAQYY
90
GEIGIGTPPQ
100
CFTVVFDTGS
110
SNLWVPSIHC
120
KLLDIACWIH
130
HKYNSGKSST
140
YVKNGTTFAI
150
HYGSGSLSGY
160
LSQDTVSVPC
170
NSASSGVGGI
180
KVERQTFGEA
190
TKQPGLTFIA
200
AKFDGILGMA
210
YPRISVNNVV
220
PVFDNLMQQK
230
LVDKNIFSFY
240
LNRDPGAQPG
250
GELMLGGIDS
260
KYYKGSLDYH
270
NVTRKAYWQI
280
HMDQVAVGSS
290
LTLCKGGCEA
300
IVDTGTSLIV
310
GPVEEVRELQ
320
KAIGAVPLIQ
330
GEYMIPCEKV
340
PSLPDVTVTL
350
GGKKYKLSSE
360
NYTLKVSQAG
370
QTICLSGFMG
380
MDIPPPGGPL
390
WILGDVFIGR
400
YYTVFDRDLN
410
RVGLAEAATL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031904 | endosome lumen |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0045121 | membrane raft |
| Molecular Function | GO:0004190 | aspartic-type endopeptidase activity |
| Biological Process | GO:0097194 | execution phase of apoptosis |
| Biological Process | GO:1901143 | insulin catabolic process |
| Biological Process | GO:0038020 | insulin receptor recycling |
| Biological Process | GO:0042159 | lipoprotein catabolic process |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0070201 | regulation of establishment of protein localization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.