Search Results

Overview

Uniprot ID	A0A286ZXQ5
Protein Name	-
Gene Name	LOC100626015
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
600	VNRFCLSKPGVYKVT
605	LSKPGVYKVTPRSCH

Function

Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions

Protein Sequence

10 MGGCRGVRPP 20 GPVVVAATVM 30 VLLSCVGPAR 40 GSEDIVVGCG 50 GFVKSDVEIN 60 YSLIEGDFIL 70 KIEPPLGWSF 80 EPTTVELYVD 90 GVSDICTKGG 100 DINFVFTGFS 110 VNGKVLSKGQ 120 PLGPAGVQVS 130 LRSTGTDAKI 140 QSTVTQPGGK 150 FAFFKVLPGD 160 YEILATHPTW 170 ALKEASTTVR 180 VTNSNANAAG 190 PLIVAGYNVS 200 GSVRSDGEPM 210 KGVKFLLFSS 220 SVSKEDVLGC 230 NISPVPGFQP 240 QDESLVYLCH 250 VVSKEDGSFS 260 FYSLPNGGYT 270 VIPFYRGERI 280 TFDVAPSRLD 290 FTVEHDSLKI 300 EPVFHVMGFS 310 VTGRVLNGPE 320 GEGVPDAVVT 330 LNNQIKVRTK 340 ADGSFRLENI 350 TTGTYTIHAQ 360 KEHLYFETVT 370 IKIAPNTPQL 380 ADIIATGFSV 390 CGQISILRFP 400 DTVKQMSKYK 410 VVLSSQDKDK 420 SLVTVETDAQ 430 GSFCFKAKPG 440 TYKVQVMVPE 450 VETRAGLTLK 460 PQTLLLAVTD 470 RPVMDVAFVQ 480 FLASVSGKVS 490 CLDTCGDLLV 500 TLQSLSRQGE 510 KRSLQLSGKL 520 NSMTFTFDNV 530 LPGKYKTSIM 540 HEDWCWKNKS 550 LEVEVLEEDV 560 SAVEFRQTGY 570 MLRCSLSHAI 580 TLEFYQDGNG 590 PENVGIYNLS 600 KGVNRFCLSK 610 PGVYKVTPRS 620 CHRFEQAFYT 630 YDTSSPSILT 640 LTAIRHHVLG 650 TITTDKMMDV 660 TVTIKSSIDS 670 EPALVLGPLK 680 SVQELRREQQ 690 LAEIESRRQE 700 REKNGGEEGG 710 EGGTKPPVQE 720 MVDELQGPFS 730 YDFSYWARSG 740 EKITVTPSSK 750 ELLFYPPSME 760 ATVSGESCPG 770 KLIEIQGKAG 780 LFLEGQIHPE 790 LEGVEIVISE 800 KGASSPLITV 810 FTDDKGAYSV 820 GPLHSDLEYT 830 VSSQKEGYVL 840 TAVEGTIGDF 850 KAYALAGVSF 860 EIKAEDDQPL 870 PGVLLSLSGG 880 VFRSNLLTQD 890 NGILTFSNLS 900 PGQYYFKPMM 910 KEFRFEPSSQ 920 MIEVQEGQNL 930 KITITGYRTA 940 YSCYGTVSSL 950 NGEPEQGVAV 960 EAVGQNDCSI 970 YGEDTVTDEE 980 GKFRLRGLLP 990 GCVYHVQLKA 1000 EGNDHIERAL 1010 PHHRVITVGN 1020 NDIDDVNIIV 1030 FRQINQFDLS 1040 GNVITSSEYL 1050 PTLWVKLYKS 1060 DNLDNPIQTV 1070 SLGQSLFFHF 1080 PPLLRDGQNY 1090 VVLLDSTLPK 1100 SQYDYVLPQV 1110 TFTAAGYHKH 1120 ITLIFNPARK 1130 LPEQDIAQGS 1140 YIALPLTLLV 1150 LLAGYNHDKL 1160 IPLLLQLTSR 1170 LQGVRALGQT 1180 ASDGSGPEDA 1190 KRQAKKQKTR RT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0160064	multi-pass translocon complex
Molecular Function	GO:0030246	carbohydrate binding
Molecular Function	GO:0043022	ribosome binding
Biological Process	GO:0160063	multi-pass transmembrane protein insertion into ER membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.