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Overview

Uniprot IDA0A286ZXW1
Protein NameAcetyl-CoA acetyltransferase, mitochondrial
Gene NameACAT1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
174 INSYTRSKAAWEAGK
181 KAAWEAGKFRSEVIP
219 FNKVPKLKTVFQKEN
258 AAKRLNVKPLARIAA
289 YAVPKVLKDAGLKKE

Function

This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism

Protein Sequence

10 MAVLSVLVRG 20 ACGRSLLLRR 30 RMQEIRYVER 40 SYVSKPTLNE 50 VVIVSATRTP 60 IGSFLGSLSS 70 LPATKLGSIA 80 IQGAIEKAGI 90 PKEEVKEVYM 100 GNVLQGGEGQ 110 APTRQAVLGA 120 GLPISTPCTT 130 INKVCASGMK 140 AIMMASQNLM 150 CGHQGNCAEN 160 TAKKLNIPRD 170 EQDTYAINSY 180 TRSKAAWEAG 190 KFRSEVIPVT 200 ISVKGKPDTV 210 VKEDEEYKRV 220 DFNKVPKLKT 230 VFQKENGTVT 240 AANASTLNDG 250 AAAVVLMTAD 260 AAKRLNVKPL 270 ARIAAFADAA 280 VDPIDFPIAP 290 AYAVPKVLKD 300 AGLKKEDVTM 310 WEVNEAFSVV 320 VLANIKMLEI 330 DPQKVNINGG 340 AVSLGHPIGM 350 SGARIVVHLA 360 HALKQGEYGL 370 ASICNGGGGA SAMLIQKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0003985 acetyl-CoA C-acetyltransferase activity
Molecular Function GO:0046872 metal ion binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.