Search Results
Overview
| Uniprot ID | A0A286ZXY5 |
|---|---|
| Protein Name | Nuclear valosin-containing protein-like |
| Gene Name | NVL |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | KTDPIPLKKTPARAS |
| 785 | ADRLAILKTITKNGT |
Function
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity
Protein Sequence
10
MKPRPARFVD
20
NKLKQRVIQG
30
CSKAYGVSQY
40
LTSNRCGKYV
50
DTGVLASDLQ
60
RMYSIDYGRR
70
KRNAFRIQVE
80
KVFSIISSEK
90
ELKSLTELED
100
EHLAKRARHG
110
EEDNEYTESY
120
SDDDSNMEDY
130
PDPQSANHMN
140
SSLLSLYRKG
150
NSDSVSSTPE
160
MEQRETTVST
170
PRTTSKTDPI
180
PLKKTPARAS
190
EGGWFIDKTP
200
GGKKDSFFSD
210
LADEKNNHKK
220
PISEIEDSKD
230
SSLLESNKKR
240
KGRLNNKESK
250
RKKEDLQEVD
260
GEIEAVLQKK
270
AKARGLELQI
280
SNVKFEDVGG
290
NDTTLKEVCK
300
MLIHMRHPEV
310
YHHLGVIPPR
320
GVLLHGPPGC
330
GKTLLAHAIA
340
GARGLVGAVA
350
SGLHCSELDL
360
PILKVAATEI
370
VSGVSGESEQ
380
KLRELFEQAV
390
SNAPCILFID
400
EIDAITPKRE
410
VASKDMERRI
420
VAQLLTCMDD
430
LNNMAATARV
440
LVIGATNRPD
450
SLDPALRRAG
460
RFDREICLGI
470
PDEASRERIL
480
QTLCRKLRLP
490
ETFRFRHLAH
500
LTPGFVGADL
510
MALCREAAVC
520
AVNRVLMKQQ
530
EQQKENPENE
540
GLPSKGGQEE
550
GIGTEPTSKG
560
QDELQRLLGL
570
LRNQDPLSEE
580
QLQGLCIELN
590
DFIVALSSVQ
600
PSAKREGFVT
610
VPNVTWADIG
620
ALEDIREELT
630
MAILAPIRNP
640
DQFKALGLVT
650
PAGVLLAGPP
660
GCGKTLLAKA
670
VANESGLNFI
680
SVKGPELLNM
690
YVGESERAVR
700
QVFQRAKNSA
710
PCVIFFDEVD
720
ALCPRRSVRE
730
SGASVRVVNQ
740
LLTEMDGLET
750
RQQVFIMAAT
760
NRPDIIDPAI
770
LRPGRLDKTL
780
FVGLPPPADR
790
LAILKTITKN
800
GTKPPLDADV
810
NLEALAGDLR
820
CDCYTGADLS
830
ALVREASICA
840
LKQEMARHKS
850
GNEKGELKIS
860
QKHFEEAFKK
870
VKSSISKEDQ
880
AMYEALQWSL
SR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000176 | nuclear exosome (RNase complex) |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005697 | telomerase holoenzyme complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:1990275 | preribosome binding |
| Biological Process | GO:1904749 | regulation of protein localization to nucleolus |
| Biological Process | GO:0042273 | ribosomal large subunit biogenesis |
| Biological Process | GO:0042254 | ribosome biogenesis |
| Biological Process | GO:0006364 | rRNA processing |
| Biological Process | GO:1905323 | telomerase holoenzyme complex assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.