Overview
| Uniprot ID | A0A286ZYC3 |
|---|
| Protein Name | Beta-hexosaminidase |
|---|
| Gene Name | HEXB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 359 |
NMISAMKKRPIVWQE |
Function
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida
Protein Sequence
10
MAMERHGWRW
20
LPGLLALLAA
30
LVVPKGWARD
40
TSGAESLGLW
50
PLPFAVDISP
60
RSLHLSPNNF
70
FFGHSPTSKA
80
GSSCEILQEA
90
FRRYYDFIFG
100
FYKWHQGSYQ
110
LCFGTELQQL
120
QVHVESECDT
130
FPSISSNESC
140
LETFSQLIYQ
150
DSYGTFTVNE
160
SEIIDFPRFP
170
HRGILIDTGR
180
HFLSVKTIFK
190
TLDAMAFNKF
200
NVLHWHIVDD
210
QSFPYQSINF
220
PLLSSKGSYS
230
LSHVYTPNDV
240
RMVIEYARIR
250
GIRVMPEFDT
260
PGHSRSWGKG
270
QKDLLTPCYR
280
KQVLSGTFGP
290
INPILNTTYN
300
FLSKFFKEIS
310
TVFPDEFIHI
320
GGDEVDFDCW
330
ASNSEILQFM
340
QEKGFSKNFT
350
KLQSFYVFKI
360
SNMISAMKKR
370
PIVWQEAFDG
380
RDKFMPGTVV
390
QVWKIEDYKW
400
EQSLITKAGF
410
PVILSAPWYL
420
DLISYGQDWK
430
NYYEVEPQDF
440
PGSDKERKRV
450
LGGEACLWGE
460
YVDATNLTPR
470
LWPRASAVGE
480
RLWSHKDVRD
490
IHDAYSRLTI
500
HRCRMVRRGI
510
AAEPLFTGYC
NHEHRM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0060473 |
cortical granule |
| Cellular Component |
GO:0005764 |
lysosome |
| Molecular Function |
GO:0004563 |
beta-N-acetylhexosaminidase activity |
| Biological Process |
GO:1901135 |
carbohydrate derivative metabolic process |
| Biological Process |
GO:0005975 |
carbohydrate metabolic process |
| Biological Process |
GO:0006629 |
lipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.