Overview
| Uniprot ID | A0A286ZYE7 |
|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein D-like |
|---|
| Gene Name | HNRNPDL |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 142 |
GSKINASKNQQDDGK |
| 162 |
LSWDTSKKDLTEYLS |
| 180 |
EVVDCTIKTDPVTGR |
| 204 |
KDAASVDKVLELKEH |
| 209 |
VDKVLELKEHKLDGK |
| 216 |
KEHKLDGKLIDPKRA |
| 234 |
KGKEPPKKVFVGGLS |
| 288 |
YTDEEPVKKLLESRY |
| 302 |
YHQIGSGKCEIKVAQ |
| 311 |
EIKVAQPKEVYRQQQ |
Function
Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence
Protein Sequence
10
MEVPPRLSQV
20
PPPLFPSAPA
30
TLASRSLSHW
40
RPRAPRQLAP
50
LLPSLAPSSA
60
RQGARRAQRH
70
VTAQQPSRLA
80
GVAAIKGGRR
90
RRPDLFRRHF
100
KSSSIQRSAA
110
AAAATRTARP
120
HPPADNPAAM
130
EDMNEYSNIE
140
EFAEGSKINA
150
SKNQQDDGKM
160
FIGGLSWDTS
170
KKDLTEYLSR
180
FGEVVDCTIK
190
TDPVTGRSRG
200
FGFVLFKDAA
210
SVDKVLELKE
220
HKLDGKLIDP
230
KRAKALKGKE
240
PPKKVFVGGL
250
SPDTSEEQIK
260
EYFGAFGEIE
270
NIELPMDTKT
280
NERRGFCFIT
290
YTDEEPVKKL
300
LESRYHQIGS
310
GKCEIKVAQP
320
KEVYRQQQQQ
330
QKGGRGAAAG
340
GRGGTRGRGR
350
GQGQNWNQGF
360
NNYYDQGYGN
370
YNSAYGGDQN
380
YSGYGGYDYT
390
GYNYGNYGYG
400
QGYADYSGQQ
410
STYGKASRGG
420
GNHQNNYQPY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:1990904 |
ribonucleoprotein complex |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0010468 |
regulation of gene expression |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.