Overview
| Uniprot ID | A0A286ZZ18 |
|---|
| Protein Name | IST1 homolog |
|---|
| Gene Name | IST1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 127 |
VADQLCAKYSKEYGK |
| 130 |
QLCAKYSKEYGKLCR |
| 134 |
KYSKEYGKLCRTNQI |
Function
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST
Protein Sequence
10
MLGSGFKAER
20
LRVNLRLVIN
30
RLKLLEKKKT
40
ELAQKARKEI
50
ADYLAAGKDE
60
RARIRVEHII
70
REDYLVEAME
80
ILELYCDLLL
90
ARFGLIQSMK
100
ELDSGLAESV
110
STLIWAAPRL
120
QSEVAELKIV
130
ADQLCAKYSK
140
EYGKLCRTNQ
150
IGTVNDRLMH
160
KLSVEAPPKI
170
LVERYLIEIA
180
KNYNVPYEPD
190
SVVMAEAPPG
200
VETDLIDVGF
210
TDDVKKGGSG
220
RGGGGGFTAP
230
VGGPDGTVPM
240
PMPMPMPSPS
250
TPFSYPLPKG
260
PVDDINADKN
270
VSSQIVGPGP
280
KPEASAKTPS
290
RPVDTHDNFV
300
LPELPSVPDT
310
LPTASAGANT
320
SASEDIDFDD
330
LSRRFEELKK
KT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.