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Overview

Uniprot ID	A0A286ZZP8
Protein Name	Signal recognition particle subunit SRP72
Gene Name	SRP72
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
111	SANQQTDKLKKRYDE
192	QAMKILQKAEDLCRR
274	DQNVFDSKKKVKLTN
37	RALKTVNKILQIHKD
443	IREAANFKLKYGRKK

Function

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER. Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68. Can bind 7SL RNA with low affinity. The SRP complex possibly participates in the elongation arrest function

Protein Sequence

10 MASGGGGGGV 20 SVPALWSEVN 30 RYGQNGDFTR 40 ALKTVNKILQ 50 IHKDDVTALH 60 CKVVCLIQNG 70 SFKEALNVIN 80 THTKVLANNS 90 LSFEKAYCEY 100 RLNRIENALK 110 TIESANQQTD 120 KLKKRYDECL 130 AVYRDLVRNS 140 QDDYDEERKT 150 NLSAVVAAQS 160 NWEKVVPENL 170 GLQEGTHELC 180 YNTACALIGQ 190 GQLNQAMKIL 200 QKAEDLCRRS 210 FSEDSDGAEE 220 DPQAELAIIH 230 GQMAYILQLQ 240 GRTEEALQLY 250 NQIIKLKPTD 260 VALLAVIANN 270 IITINKDQNV 280 FDSKKKVKLT 290 NAEGVEFKLS 300 KKQLQAIEFN 310 KALLAMYTNQ 320 AEQCRKISTS 330 LQSQSPQHLL 340 PVLIQAAQLC 350 REKQHTKAIE 360 LLQEFSDQHP 370 ENAAEIKLTM 380 AQLKISQACL 390 ILRSIEELKH 400 KPGMVSALVT 410 MYSHEEDIDS 420 AIEVFTQAIQ 430 WYQSHQPKSP 440 AHLSLIREAA 450 NFKLKYGRKK 460 EAVSDLEQLW 470 KQNPKDIHTL 480 AQLISAYSLV 490 DPEKAKALSK 500 HLPSSDSMSL 510 KVDVDALENS 520 PGATYVRKKG 530 GKVYGQISHF 540 FINCYTGKLP 550 KNYDPKVTPD 560 PERWLPMRER 570 SYYRGRKKGK 580 KKDQIGKGTQ 590 GASAGASSEL 600 DASKTVSSPP 610 TSPRPGSAAA 620 ASTSTSNIIP 630 PRHQKPAGAP 640 ATKKKQPQKK KRGGRGGW

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005786	signal recognition particle, endoplasmic reticulum targeting
Molecular Function	GO:0008312	7S RNA binding
Biological Process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.