Overview
| Uniprot ID | A0A287A0G9 |
|---|
| Protein Name | Eukaryotic translation initiation factor 3 subunit K |
|---|
| Gene Name | EIF3K |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 140 |
GFEDSVRKFICHVVG |
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression
Protein Sequence
10
MSPMPHTGTG
20
PRSSRPPLWR
30
YNPENLATLE
40
RYVETQAKEN
50
AYDLEANLAV
60
LKLYQFNPAF
70
FQTTVTAQIL
80
LKALTNLPHT
90
DFTLCKCMID
100
QAHQEERPIR
110
QILYLGDLLE
120
TCHFQAFWQA
130
LDENMDLLEG
140
ITGFEDSVRK
150
FICHVVGITY
160
QHIDRWLLAE
170
MLGDLTDGQL
180
KVWMSKYGWS
190
ADESGQIFIC
200
SQEESIKPKN
210
IVEKIDFDSV
SSIMASSQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016282 |
eukaryotic 43S preinitiation complex |
| Cellular Component |
GO:0033290 |
eukaryotic 48S preinitiation complex |
| Cellular Component |
GO:0005852 |
eukaryotic translation initiation factor 3 complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0043022 |
ribosome binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0003743 |
translation initiation factor activity |
| Biological Process |
GO:0001732 |
formation of cytoplasmic translation initiation complex |
| Biological Process |
GO:0006446 |
regulation of translational initiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.