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Overview

Uniprot ID	A0A287A0I8
Protein Name	Drebrin
Gene Name	DBN1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
271	EEETQMKKSESEVEE
295	DNPREFFKQQERVAS

Function

Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus

Protein Sequence

10 MAGVSFSGHR 20 LELLAAYEEV 30 IREESSADWA 40 LYTYEDGSDD 50 LKLAASGDGG 60 LQELSGHFEN 70 QKVMYGFCSV 80 KDSQAALPKY 90 VLINWVGEDV 100 PDARKCACAS 110 HVAKVAEFFQ 120 GVDVIVNASS 130 VEDIDAGAIG 140 QRLSNGLARL 150 SSPVLHRLRL 160 REDENAEPVG 170 TTYQKTDAAV 180 EMKRINREQF 190 WEQAKKEEEL 200 RKEEERKKAL 210 DERLRFEQER 220 MEQERQEQEE 230 RERRYREREQ 240 QIEEHRRKQQ 250 TLEAEEAKRR 260 LQEQSIFGDQ 270 RDEEEETQMK 280 KSESEVEEAA 290 AIIAQRPDNP 300 REFFKQQERV 310 ASASAGSCDV 320 PSPFNHRPGR 330 PYCPFIKASD 340 SGPSSSSSSS 350 SSPPRTPFPY 360 ITCHRTPNLS 370 SSLPCSHLDS 380 HRRMAPTPIP 390 ARSPSDSSTA 400 STPVAEQIER 410 ALDEVTSSQP 420 PPLPPPPPPA 430 QETQEPSPGL 440 DSEETSKEAR 450 EAAPQAWAGP 460 VEEPPQAPEP 470 PQGRGSPPED 480 LMFMASTEQA 490 VLAAPLEPAM 500 AGASAADTLV 510 ADAIEADTAA 520 ADTAVANTVT 530 PAAASLIDLW 540 PGNGEEASAP 550 QAEPRAPTPP 560 SGAEVPLAEV 570 PLLDEVAQEP 580 LPPAGEGSAN 590 LLNFDELPEP 600 PATFCDQEEE 610 VEGVSLAVPQ 620 APTLPSALEE 630 LDLEPEPEPH 640 LLTNGETTQK 650 EGTQASEGYF 660 SQSQEEEFAQ 670 SEELCAKAPP 680 PVFYNKPPEI 690 DITCWDADPV 700 PEEEEGFEGG D

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070161	anchoring junction
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0030426	growth cone
Molecular Function	GO:0003779	actin binding
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007399	nervous system development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.