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Overview

Uniprot IDA0A287A181
Protein NameProtein 4.1
Gene NameEPB41L3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
379 RAAKRLWKVCVEHHT
399 LPEAPPKKFLTLGSK

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MTTESGSDSE 20 SKPEQEAEPQ 30 EAAGPQGHAG 40 GQPGPEPGAE 50 EQPQAPEQFE 60 EAAAHSTPVR 70 KEVTDKEQEF 80 AAAAAKQLEY 90 QQFEDDKLSQ 100 KSSSSKLSRS 110 PLKIVKKPKS 120 MQCKVILLDG 130 SEYTCDVEKR 140 SRGQVLFDKV 150 CEHLNLLEKD 160 YFGLTYRDAE 170 NQKNWLDPAK 180 EIKKQIRSGA 190 WHFSFNVKFY 200 PPDPAQLSED 210 ITRYYLCLQL 220 RDDIVSGRLP 230 CSFVTLALLG 240 SYTVQSELGD 250 YDPDECGSDY 260 VSEFRFAPNH 270 TKELEDKVIE 280 LHKSHRGMTP 290 AEAEMHFLEN 300 AKKLSMYGVD 310 LHHAKDSEGV 320 DIMLGVCASG 330 LLIYRDRLRI 340 NRFAWPKVLK 350 ISYKRNNFYI 360 KIRPGEFEQF 370 ESTIGFKLPN 380 HRAAKRLWKV 390 CVEHHTFFRL 400 LLPEAPPKKF 410 LTLGSKFRYS 420 GRTQAQTRRA 430 SALIDRPAPY 440 FERSSSKRYT 450 MSRSLDGASV 460 NENHEMYMKD 470 SVSAAEVGTG 480 QYATTKGISQ 490 TNLITTVTPE 500 KKAEEERDEE 510 EERRKKAEEA 520 TPVATVRHEG 530 KSPGLGTDSC 540 SLSPPSAHRA 550 PASPTELRRR 560 CKEKERPPPG 570 AEPSRDPGHL 580 CGEPTSDSDG 590 QGKPRLRDQD 600 VAFSYKQQAG 610 RGATLFSFSL 620 QLPASFPSLL 630 DDDGYLSFPS 640 LSETSLLPQS 650 LQHYLPIRSP 660 SLVPCFLFIF 670 FFLLSASFSV 680 PYALTLSFPL 690 ALCLCYLEPK 700 AASLSASLDN 710 DPSDSSEEEV 720 CTSENTCETL 730 TLDKTQDDLM 740 KHQTNISELK 750 RTFLETSTDT 760 AVTNEWEKRL 770 STSPVRLAAR 780 PEEAPMIEPL 790 VPEETKQSSG 800 EKLMDGSEIF 810 SLLESARKPT 820 EFIGGVTSTS 830 QSWVQKTETK 840 TESSETETET 850 TQRPQPLSTE 860 TVVQETVLVE 870 ERHVMSVHAS 880 GDASSTAGDG 890 VDAAAQAASA 900 EASGVKGKEG 910 SALTEGAKED 920 KGEVADRAVL 930 EQEVMATASQ 940 EPEEERLSAA 950 IHVSETLEQK 960 PHFESSTVKT 970 ETISFGSVSP 980 GGIKLEISTK 990 EVPVVHTETK 1000 TITYESSQVD 1010 LGADLEPGVL 1020 MSAQTITSET 1030 TSTTTTTHIT 1040 RTVKGGISET 1050 RIEKRIVITG 1060 DADIDHDQAL 1070 AQAIKEAKEQ 1080 HPDMSVTKVV 1090 VHKETEITPE DGED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030866 cortical actin cytoskeleton organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.