Overview
| Uniprot ID | A0A287A1V6 |
|---|
| Protein Name | Small glutamine-rich tetratricopeptide repeat-containing protein alpha |
|---|
| Gene Name | SGTA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 160 |
CIDPSYSKAYGRMGL |
| 184 |
EAVAYYRKALELDPD |
| 200 |
ETYKSNLKVAELRLR |
Function
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity
Protein Sequence
10
MDNKKRLAYA
20
IIRFLHDQLR
30
HGGLSPDAQE
40
SLEVAIQCLE
50
TAFGVTVEDS
60
DLALPQTLSE
70
IFEAAASGKE
80
VPQDLRSPQQ
90
TPPSEEDSAE
100
AERLKTEGNE
110
QMKVENFEAA
120
VHFYGKAIEL
130
NPSNAVYFCN
140
RAAAYSKLGN
150
YAGAVQDCER
160
AICIDPSYSK
170
AYGRMGLALS
180
SLNKHTEAVA
190
YYRKALELDP
200
DNETYKSNLK
210
VAELRLREAP
220
SPTGGVGSFD
230
IAGLLNNPSF
240
MSMASNLMNN
250
PQVQQLMSGM
260
ISGGHNPLGT
270
PGTSPSQNDL
280
ASLIQAGQQF
290
AQQMQQQNPE
300
LIEQLRSQIR
310
SRTPSASNDD
QQE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0072380 |
TRC complex |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Biological Process |
GO:0006620 |
post-translational protein targeting to endoplasmic reticulum membrane |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.