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Overview

Uniprot IDA0A287A225
Protein NameDiphosphomevalonate decarboxylase
Gene NameMVD
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
205 ALLRFRAKALVPARM
33 TTTAAISKDFTKDRI

Function

Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis

Protein Sequence

10 SRDEELILPI 20 NSSLSVTLHQ 30 HQLKTTTTAA 40 ISKDFTKDRI 50 WLNGREEDVG 60 QPRIQACLRE 70 IRRLARKRKS 80 DGDEDALPLC 90 LSYKVHVASV 100 NNFPTAAGLA 110 SSAAGFACLA 120 CALARVYGVE 130 GDLSEVARRG 140 SGSACRSLYG 150 GFVEWQMGQR 160 ADGKDSIAQQ 170 VAPESHWPEL 180 RVLILVVSAE 190 KKLMGSTAGM 200 QTSVETSALL 210 RFRAKALVPA 220 RMAEMARCIR 230 ERDFQAFGQL 240 TMKDSNQFHA 250 TCLDTFPPIS 260 YLSDTSQRVI 270 RLVHRFNAHH 280 GCTKVAYSFD 290 AGPNAVIFAL 300 DDTVPEFVAA 310 VQHSFPPEPN 320 GDKFLQGLPV 330 EPALLSDELK 340 AALGTDPTPG 350 GIRYIIATQV 360 GPGPQVLDDP 370 GAHLLGPDGL PKLAS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004163 diphosphomevalonate decarboxylase activity
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.