Overview
| Uniprot ID | A0A287A3I8 |
|---|
| Protein Name | Nucleoporin SEH1 |
|---|
| Gene Name | CEP192 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 251 |
DVRIFTLKPVRKELT |
Function
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex
Protein Sequence
10
MFVARSIAAD
20
HKDLIHDVSF
30
DFHGRRMATC
40
SSDQSVKVWD
50
KSESGDWHCT
60
ASWKTHSGSV
70
WRVTWAHPEF
80
GQVLASCSFD
90
RTAAVWEEIV
100
GESNDKLRGQ
110
SHWVKRTTLV
120
DSRTSVTDVK
130
FAPKHMGLML
140
ATCSADGIVR
150
IYEAPDVMNL
160
SQWSLQHEVS
170
CKLSCSCISW
180
NPSSSRAHPP
190
MIAVGSDDGS
200
PNAMAKVQIF
210
EYNENTRKYA
220
KAETLMTVTD
230
PVHDIAFAPN
240
LGRSFHILAI
250
ATKDVRIFTL
260
KPVRKELTSS
270
GGPTKFEIQV
280
VAQFDNHNSQ
290
VWRVSWNITG
300
TVLASSGDDG
310
CVRLWKANYM
320
DNWKCTGILK
330
GNGSPVSGSS
340
QQGNANPSLG
350
SNTPNLQHSL
360
NGSSASRNGK
370
RAPFPLPQRR
380
LTSPKIHQQP
AYY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007059 |
chromosome segregation |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.