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Overview

Uniprot IDA0A287A3L2
Protein NameProteasome adapter and scaffold protein ECM29
Gene NameECPAS
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1404 RYSPDVLKNHAKEVL
1655 KLMCERLKLSTWKVQ
309 GDIPLKTKEGAVLKP
688 YPEKLAAKFVDKTEW
970 LMTGKRAKHEVSGET

Function

Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress

Protein Sequence

10 MYHIDCRDQL 20 ERVFLRLGHA 30 ETDEQLQNII 40 SKFLPPVLLK 50 LSSTQEGVRK 60 KVMELLVHLN 70 KRIKSRPKIQ 80 LPVETLLVQY 90 QDPAAVSFVT 100 NFTIIYVKMG 110 YPRLPVEKQC 120 ELAPTLLTAM 130 EGKPQPQQDS 140 LMHLLIPTLF 150 HMKYPVESSK 160 SASPFNLAEK 170 PKTVQLLLDF 180 MLDVLLMPYG 190 YVLNESQSRQ 200 NSSSAQGSSS 210 NSGGGSGIPQ 220 PPPGMSFYAA 230 KRVIGDNPWT 240 PEQLEQCKLG 250 IVKFIEAEQV 260 PELEAVLHLV 270 IASSDTRHSV 280 ATAADLELKS 290 KQSLIDWNNP 300 AIINKMYKVY 310 LGDIPLKTKE 320 GAVLKPELKR 330 DPVSTRVKLK 340 IVPHLLRSRQ 350 AAETFPANIQ 360 VVYDGLFGTN 370 TNSKLRTLSL 380 QFVHHICVTC 390 PEVKIKPLGP 400 MLLNGLTKLI 410 NEYKEDPKLL 420 SMAYSAVGKL 430 SSRMPHLFTK 440 DIALVQQLFE 450 ALCKEEPETR 460 LAIQEALSMM 470 VGAYSTLEGA 480 QRTLMEALVA 490 SYLIKPEVQV 500 RQVAVKFAST 510 VFPSDHIPSR 520 YLLLLAAGDP 530 REEVHGEAQR 540 VLRCLPGRNR 550 KESSSKQMPS 560 FPEMVYYIQE 570 KASHRMKTPA 580 KYMTGTTVLP 590 FNPAAFGEIV 600 LYLRMCLAHS 610 AGVVPTSQSL 620 ADMQDHAPAI 630 GRYIRTLMSS 640 SQATSSSSSS 650 SSSKSGETNP 660 VQIYIGLLQQ 670 LLAGVGGLPV 680 MYCLLEAVSV 690 YPEKLAAKFV 700 DKTEWIKSLM 710 NSSKEEMREL 720 AALFYSVVVS 730 TVSGNELKSM 740 IEQLIKTTKD 750 NHSPEIQHGS 760 LLALGFTVGR 770 YLAKKKMKMA 780 EQQGVETNAD 790 FLPEQEELIQ 800 SATETIGSFL 810 DSTSPLLAIA 820 ACTALGEIGR 830 NGPLPIPSEG 840 SGFTKLHLVE 850 SLLNRIPSSK 860 ETNKMKERAI 870 QTLGYFPVGD 880 GDFPHQKLLL 890 QGLMDSVEAK 900 QIELQFTIGE 910 AITSAAIGTS 920 SVAARDAWLV 930 TEEEYTPPAE 940 LSQDVASKGL 950 GLVYELGNEQ 960 DQQELVSTLV 970 ETLMTGKRAK 980 HEVSGETVVF 990 QGGSLGKTPD 1000 GQGLSTYKEL 1010 CSLASDLSQP 1020 DLVYKFMNLA 1030 NHHAMWNSRK 1040 GAAFGFNVIA 1050 TRAGEQLAPF 1060 LPQLVPRLYR 1070 YQFDPNLGIR 1080 QAMTSIWNAL 1090 VTDKSMVDKY 1100 LKEILQDLVK 1110 NLTSNMWRVR 1120 ESSCLALNDL 1130 LRGRPLDDII 1140 DKLPEIWETL 1150 FRVQDDIKES 1160 VRKAAELALK 1170 TLSKVCVKMC 1180 DPAKGAAGQK 1190 TIAVLLPCLL 1200 DKGMMSPVTE 1210 VRALSINTLV 1220 KISKSAGAML 1230 KPHAPKLIPA 1240 LLESLSVLEP 1250 QVLNYLSLRA 1260 TDQEKAAMDS 1270 ARLSAAKSSP 1280 MMETINMCLQ 1290 YLDVSVLGEL 1300 VPRLCELIRS 1310 GVGLGTKGGC 1320 ASVIVSLTTQ 1330 CPQDLTPYSG 1340 KLMSALLSGL 1350 TDRNSVIQKS 1360 CAFAMGHLVR 1370 TSRDSSTEKL 1380 LQKLNGWYME 1390 KEVYKTSCAL 1400 TVHAIGRYSP 1410 DVLKNHAKEV 1420 LPLAFLGMHE 1430 IADEEKAEKE 1440 ECNLWTEVWQ 1450 ENVPGSFGGI 1460 RLYLQELITI 1470 AQKALQSQSW 1480 KMKAQGAIAM 1490 ASIAKQTSSL 1500 VPPYLGMILT 1510 ALLQGLAGRT 1520 WAGKEELLKA 1530 IACVVTACSA 1540 ELEKPVPNQP 1550 SINEILQAVL 1560 KECGKENPKY 1570 KIVAISCTAD 1580 VLKATKEDRF 1590 QEFADIVIPL 1600 IKKNSPESIG 1610 VRTSKNEDEN 1620 EKEKELQLES 1630 LLGAFESLGK 1640 AWPRNVETQR 1650 CYRQELCKLM 1660 CERLKLSTWK 1670 VQLGVLQSMN 1680 AFFQGLMLLE 1690 EEHADPEALA 1700 EILLETCKSI 1710 TYSLENKTYS 1720 SVRTEALSVI 1730 ELLLKKLEES 1740 KQWESLTSEC 1750 RVLLIESLAT 1760 METDSRPELQ 1770 EKASLLKKTL ENLE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0005771 multivesicular body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Molecular Function GO:0060090 molecular adaptor activity
Biological Process GO:0043248 proteasome assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.