Overview
| Uniprot ID | A0A287A3T1 |
|---|
| Protein Name | Toll-interacting protein |
|---|
| Gene Name | TOLLIP |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 66 |
VVQAKLAKNYGVTRM |
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P)
Protein Sequence
10
MATTVSTQRG
20
PVYLGELPQD
30
FLRITPTQQQ
40
QQIQLDAQAA
50
QQLQFGGTLG
60
TVGRLSITVV
70
QAKLAKNYGV
80
TRMDPYCRLR
90
LGYAVYETPT
100
AHNGAKNPRW
110
NKVIQCTVPG
120
VDSFYLEIFD
130
ERAFSMDDRI
140
AWTHVTIPES
150
LKQGKVEDEW
160
YSLSGRQGDD
170
KEGMVNLVMS
180
YTSLPAAVVM
190
PPQPVVLMPT
200
VYQQGVGYVP
210
LAGVPAVCGP
220
GVVPVALPPA
230
VSAQPRCSEE
240
DLKAMQDMFP
250
NVDREVIRSV
260
LEAQRGSKDA
270
AINSLLQMGE
ES
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0043130 |
ubiquitin binding |
| Molecular Function |
GO:0031624 |
ubiquitin conjugating enzyme binding |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0030855 |
epithelial cell differentiation |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0070498 |
interleukin-1-mediated signaling pathway |
| Biological Process |
GO:0036010 |
protein localization to endosome |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0019900 |
kinase binding |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Molecular Function |
GO:0035325 |
Toll-like receptor binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.