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Overview

Uniprot ID	A0A287A3U2
Protein Name	Alkylglycerone-phosphate synthase
Gene Name	AGPS
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
371	TPRGIIEKSCQGPRM
478	LKKFYITKFKGFDPN
506	EKVLQHEKQVYDIAA
579	ITRECKEKGVQFAPL

Function

Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids

Protein Sequence

10 MVASGAALSD 20 LSPAPSGPGR 30 RHKAEAMAEA 40 AAAAGGTGAG 50 AGSGSAADRD 60 RDPERDGAGR 70 RLRVLSGHLL 80 GRPQEALSTN 90 ECKARRAAAA 100 ATAAPAATPA 110 AQESGIIPKK 120 RQEVMKWNGW 130 GYNDSKFFFN 140 KKGQVEFTGK 150 RYPLSGMILP 160 TFREWIENIL 170 GVSLEHKTTS 180 KASLNPSDTP 190 PSIVNEDFLH 200 DLKETNISYS 210 READDRVFRA 220 HGHCLHEIFL 230 LREGTFQRIP 240 DIVLWPTCHD 250 DVVKIVNLAC 260 KYNLCIIPIG 270 GGTSVSYGLM 280 CPADETRTII 290 SLDTSQMNRI 300 LWIDENNLTV 310 HVEAGITGQE 320 LERQLKESGY 330 CTGHEPDSLE 340 FSTVGGWVST 350 RASGMKKNIY 360 GNIEDLVVHI 370 KMVTPRGIIE 380 KSCQGPRMST 390 GPDIHHFIMG 400 SEGTLGVITE 410 ATIKIRPIPE 420 YQKYGSVAFP 430 NFEQGVACLR 440 EIAKQRCAPA 450 SIRLMDNQQF 460 QFGHALKPQV 470 SSIFTSFLDG 480 LKKFYITKFK 490 GFDPNQLSVA 500 TLLFEGDREK 510 VLQHEKQVYD 520 IAAKFGGLAA 530 GEDNGQRGYL 540 LTYVIAYIRD 550 LGLEYYVLGE 560 SFETSAPWDR 570 VVDLCRNVKE 580 RITRECKEKG 590 VQFAPLSTCR 600 QLLEKKSLLM 610 EGACHTTTEL 620 AKAMFFWMRR 630 DKEHSTERIP 640 RKGRTAPIPE 650 GLSGTLVHPR 660 FPGKAAEEDH 670 CNPPRAFFQP 680 SIWLQPSLVF 690 NPNNILIIAS 700 GGMDFPKDHY N

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005777	peroxisome
Molecular Function	GO:0008609	alkylglycerone-phosphate synthase activity
Molecular Function	GO:0071949	FAD binding
Biological Process	GO:0008611	ether lipid biosynthetic process
Biological Process	GO:0008610	lipid biosynthetic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.