Search Results
Overview
| Uniprot ID | A0A287A3W3 |
|---|---|
| Protein Name | Pyrroline-5-carboxylate reductase |
| Gene Name | PYCR3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 33 | QGLIRAGKVEAQYVL |
Function
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine
Protein Sequence
10
MAAAAETGPR
20
RVGFVGAGRM
30
AEAIAQGLIR
40
AGKVEAQYVL
50
ASAPTDRNLC
60
HFRALGCRTT
70
HSNHEVLQSC
80
SLVIFATKPH
90
VLPAVLAEVA
100
PVVTTEHILV
110
SVAAGVPLST
120
MEELLPPGAR
130
VLRVSPNLPC
140
VVQEGAMVLA
150
RGRHAGNSEA
160
ELLQTLLEAC
170
GQCEEVPEAQ
180
VDTHTGLSGS
190
GVAFVCAFSE
200
ALAEGAIKMG
210
MPSGLAYRIA
220
AQTLLGTAKM
230
LLQKGQHPAQ
240
LRTDVCTPGG
250
TTIYGLHALE
260
QGGLRAAAMS
270
AVEAATRRAK
EMRKWRG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004735 | pyrroline-5-carboxylate reductase activity |
| Biological Process | GO:0055129 | L-proline biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.