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Overview

Uniprot ID	A0A287A3X4
Protein Name	YTH domain-containing family protein
Gene Name	YTHDC1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
127	SASREPYKSQPEKTC
96	GKSVTEYKNEEYQRS

Function

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing

Protein Sequence

10 MAADSREEKD 20 GELNVLDDIL 30 TEVPEQDDEL 40 YNPESEQDKN 50 EKKGSKRKSD 60 RMESTDTKRQ 70 KPSVHSRQLI 80 SKPLSSSVSN 90 NKRMASTKGK 100 SVTEYKNEEY 110 QRSERNKRIE 120 ADRKIRLSSS 130 ASREPYKSQP 140 EKTCLRKRDS 150 ERRVKSPTPD 160 GSERIGLEVD 170 RRASRSSQSS 180 KEEVNSEEYG 190 SDHETGSSGS 200 SDEQGNNTEN 210 EEEGVEDVEE 220 DEEVEEDAEE 230 DEEVDEDGEE 240 EEEEEEEEEE 250 EEEEEEEEYE 260 QDERDQKEEG 270 NDYDTRSEAS 280 DSDSESVSFT 290 DGSVRSGSGT 300 DGSDEKKKER 310 KRARGISPII 320 FDRSGSSASE 330 SYADQTSKLK 340 YVLQDARFFL 350 IKSNNHENVS 360 LAKAKGVWST 370 LPVNEKKLNA 380 AFRSARSVIL 390 IFSVRESGKF 400 QGFARLSSES 410 HHGGSPIHWV 420 LPAGMNAKML 430 GGVFKIDWIC 440 RRELPFTKSA 450 HLTNPWNEHK 460 PVKIGRDGQE 470 IELECGTQLC 480 LLFPPDESID 490 LYQVIHKMRH 500 KRRMHSQPRS 510 RGRPSRREPV 520 RDVGRRRPEE 530 YDIHNSRKKP 540 RIDYAPEFHQ 550 RPGYLKDPRY 560 QEVDRRFSGV 570 RRDVFLNGSY 580 NDYVREFHNM 590 GPPPPWQGMT 600 PYPGMEQPPH 610 HPYYQHHAPP 620 PQAHPPYSGH 630 HPVPHEARYR 640 DKRVHDYDMR 650 VDDFLRRTQA 660 VVSGRRSRPR 670 ERDRERERDR 680 PRDNRRDRER 690 DRGRDRERER 700 ERLCDRDRDR GERGRYRR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:1990247	N6-methyladenosine-containing RNA reader activity
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0008380	RNA splicing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.