Search Results
Overview
| Uniprot ID | A0A287A3Z0 |
|---|---|
| Protein Name | Mitotic spindle assembly checkpoint protein MAD1 |
| Gene Name | MAD1L1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 81 | RAEQIRSKSHLIQVE |
Function
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling
Protein Sequence
10
MVRGKAPRDP
20
SLVFLQREVA
30
MEDLGENTTV
40
LSTLRSLNSF
50
ISQRVEGGSG
60
LDVSTPAQGS
70
LQMQYQQSMQ
80
LEERAEQIRS
90
KSHLIQVERE
100
KMQMELSHKR
110
ARVELERAAS
120
TSARSYEREV
130
DRNQELLTRI
140
RQLQEREAEA
150
EEKMKEQLER
160
YRLCQQSLDA
170
ASRKLREEED
180
SLAEAGETIS
190
ALKGRLSELQ
200
WSAMNQEMQV
210
KRLESEKQEL
220
KEQLDLQHKK
230
WQEAQQKVQE
240
LQASQDARAD
250
QEQRIKDLEQ
260
KLSLQEQDAA
270
IVRSMRSELV
280
RLPTMERELR
290
QLREENACLR
300
ETREASGLLR
310
EELEGLQRRL
320
GRQEKLQENL
330
VNLELENERL
340
LTKLQSWERL
350
GQTTGLSIRT
360
PEELSSFIVE
370
LQQRELTLKD
380
RNSTLTSSAR
390
GLEKARLQLQ
400
EEVRQVSSQL
410
LEERKKRETH
420
EALARRLQKR
430
VLLLTKERDG
440
MRAILGSYDS
450
ELTPAEYAPQ
460
LTRRLREAED
470
MVQKVHAHSS
480
EVEVQLSQAL
490
EELGGQKQRA
500
DALEMELQML
510
KSQAGPAEQS
520
FLFSREEVSA
530
LRLKIEELAQ
540
ERSRLEEDKK
550
LLEAQLERLT
560
LQGDFDQSRT
570
KVLHLSLNPA
580
SVARQRFRED
590
WQQLQEECKH
600
LRELVRALEA
610
GGPVPADLEA
620
AAGLPSSKEV
630
AELKRQVESA
640
ELKNQRLKEV
650
FQTKIQEFRK
660
ACYALTGYQV
670
DITTEGQFRL
680
TSMYAERKAD
690
CLVFKAAGPS
700
GTKMQLLETE
710
FSRTVPELIE
720
LHLLRQDSIP
730
AFLSALTLDL
FSRQTVA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:1990706 | MAD1 complex |
| Cellular Component | GO:1990728 | mitotic spindle assembly checkpoint MAD1-MAD2 complex |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0000922 | spindle pole |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007094 | mitotic spindle assembly checkpoint signaling |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.