Overview
| Uniprot ID | A0A287A426 |
|---|
| Protein Name | IST1 homolog |
|---|
| Gene Name | IST1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 143 |
VADQLCAKYSKEYGK |
| 146 |
QLCAKYSKEYGKLCR |
| 150 |
KYSKEYGKLCRTNQI |
Function
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST
Protein Sequence
10
MLGSGFKAER
20
LRVNLRLVIN
30
RLKLLEKKKR
40
PSILLLGDWS
50
GICALAELAQ
60
KARKEIADYL
70
AAGKDERARI
80
RVEHIIREDY
90
LVEAMEILEL
100
YCDLLLARFG
110
LIQSMKELDS
120
GLAESVSTLI
130
WAAPRLQSEV
140
AELKIVADQL
150
CAKYSKEYGK
160
LCRTNQIGTV
170
NDRLMHKLSV
180
EAPPKILVER
190
YLIEIAKNYN
200
VPYEPDSVVM
210
AEAPPGVETD
220
LIDVGFTDDV
230
KKGGSGRGGG
240
GGFTAPVGGP
250
DGTVPMPMPM
260
PMPSPSTPFS
270
YPLPKGPSDF
280
NGLPVGTYQA
290
FPNIHPPQIP
300
ATPPSYESVD
310
DINADKNVSS
320
QIVGPGPKPE
330
ASAKTPSRPV
340
DTHDNFVLPE
350
LPSVPDTLPT
360
ASAGANTSAS
370
EDIDFDDLSR
RFEELKKKT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.