Overview
| Uniprot ID | A0A287A4E7 |
|---|
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
|---|
| Gene Name | PRKACB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 100 |
IEHTLNEKRILQAVN |
| 31 |
KEFLAKAKEDFLKKW |
| 317 |
WIAIYQRKVEAPFIP |
Function
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR
Protein Sequence
10
MGLSRKSSEA
20
SACSSSEVSD
30
SFVKEFLAKA
40
KEDFLKKWEN
50
PAPNNAGLED
60
FERKKTLGTG
70
SFGRVMLVKH
80
KATEQYYAMK
90
ILDKQKVVKL
100
KQIEHTLNEK
110
RILQAVNFPF
120
LVRLEYSFKD
130
NSNLYMVMEY
140
VPGGEMFSHL
150
RRIGRFSEPH
160
ARFYAAQIVL
170
TFEYLHSLDL
180
IYRDLKPENL
190
LIDHQGYIQV
200
TDFGFAKRVK
210
GRTWTLCGTP
220
EYLAPEIILS
230
KGYNKAVDWW
240
ALGVLIYEMA
250
AGYPPFFADQ
260
PIQIYEKIVS
270
GKVRFPSHFS
280
SDLKDLLRNL
290
LQVDLTKRFG
300
NLKNGVSDIK
310
THKWFATTDW
320
IAIYQRKVEA
330
PFIPKFRGSG
340
DTSNFDDYEE
350
EDIRVSITEK
CGKEFCEF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004691 |
cAMP-dependent protein kinase activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.