Search Results

Overview

Uniprot IDA0A287A4R9
Protein NameCytoskeleton-associated protein 5
Gene NameCKAP5
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1128 KPDPKKAKALGVSSK
1135 KALGVSSKAKTAQGK
1369 PTPGKALKEIAIHIG
354 LAVGLRKKFGQYAGH
496 KIKECSEKVELIHGK
530 ASGAAGDKDTKDVSA
559 GGPPKKGKPAAQGGT

Function

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments

Protein Sequence

10 MGDDSEWMKL 20 PVDQKCEHKL 30 WKARLSGYEE 40 ALKIFQKVKD 50 EKSPEWSKFL 60 GLIKKFVTDS 70 NAVVQLKGLE 80 AALVYVENAH 90 VAGKTTGEVV 100 SGVVSKVFNQ 110 PKAKAKELGI 120 EICLMYIEIE 130 KGEAVQEELL 140 KGLDNKNPKI 150 IVACIETLRK 160 ALSEFGSKII 170 LLKPIIKVLP 180 KLFESREKAV 190 RDEAKLIAVE 200 IYRWIRDALR 210 PPLQNINSVQ 220 LKELEEEWVK 230 LPTGAPKPSR 240 FLRSQQELEA 250 KLEQQQSAGG 260 DAEGGGDDGD 270 EVPQIDAYEL 280 LEAVEILSKL 290 PKDFYDKIEA 300 KKWQERKEAL 310 EAVEVLVKNP 320 KLEAGDYADL 330 VKALKKVVGK 340 DTNVMLVALA 350 AKCLTGLAVG 360 LRKKFGQYAG 370 HVVPTILEKF 380 KEKKPQVVQA 390 LQEAIDAIFL 400 TTTLQNISED 410 ILAVMDNKNP 420 TIKQQTSLFI 430 ARSFRHCTAS 440 TLPKSLLKPF 450 CAALLKHIND 460 SAPEVRDAAF 470 EALGTALKVV 480 GEKAVNPFLA 490 DVDKLKLDKI 500 KECSEKVELI 510 HGKKAGLAAD 520 KKEVKPVPGR 530 TAASGAAGDK 540 DTKDVSAPKP 550 GPLKKAPATK 560 PGGPPKKGKP 570 AAQGGTGSTG 580 TKNKKGLETK 590 EIVEPELSIE 600 VCEEKASAVL 610 PAPCIQLLDS 620 SNWKERLACM 630 EEFQKAVELM 640 DRTEMPCQAL 650 VRMLAKKPGW 660 KETNFQVMQM 670 KLHIVALIAQ 680 KGNFSKTSAQ 690 IVLDGLVDKI 700 GDVKCGNNAK 710 EALTAIAEAC 720 MLPWTAEQVM 730 SMAFSQKNPK 740 NQSETLNWLS 750 NAIKEFGFSG 760 LNVKAFISNV 770 KTALAATNPA 780 VRTSAITLLG 790 VMYLYVGPSL 800 RMFFEDEKPA 810 LLSQIDAEFE 820 KMQGQNPPAP 830 TRGISKHSTS 840 GTDEGEDGDE 850 PDDGGNDVVD 860 LLPRTEISDK 870 ITSELVSKIG 880 DKNWKIRKEG 890 LDEVAGIINE 900 AKFIQPNIGE 910 LPTALKGRLN 920 DSNKILVQQT 930 LNILQQLAVA 940 MGPNIKQHVK 950 NLGIPIITVL 960 GDSKNNVRAA 970 ALATVNAWAE 980 QTGMKEWLEG 990 EDLSEELKKE 1000 NPFLRQELLG 1010 WLAEKLPTLR 1020 STPTDLILCV 1030 PHLYSCLEDR 1040 NGDVRKKAQD 1050 ALPFFMMHLG 1060 YEKMAKATGK 1070 LKPTSKDQVL 1080 AMLEKAKANM 1090 PAKPAAPAKA 1100 TSKPVGGSAP 1110 AKFQPTSAPV 1120 EDSVSGTIEP 1130 KPDPKKAKAL 1140 GVSSKAKTAQ 1150 GKKVPSKTTL 1160 KDDEDKSGPI 1170 FILVPNGKEQ 1180 RMRDEKSLKV 1190 LKWNFTTPRD 1200 EYIEQLKTQM 1210 SSCVAKWLQD 1220 EMFHSDFQHH 1230 NKALAVMVDH 1240 LESEKEGVIG 1250 CLDLILKWLT 1260 LRFFDTNTSV 1270 LMKALEYLKL 1280 LFTLLSEEEY 1290 HLTENEASSF 1300 IPYLILKVGE 1310 PKDVIRKDVR 1320 AILNRMCLVY 1330 PASKMFPFIM 1340 EGTKSKNSKQ 1350 RAECLEELGC 1360 LVESYGMNVC 1370 QPTPGKALKE 1380 IAIHIGDRDN 1390 AVRNAALNTI 1400 VTVYNVHGDQ 1410 VFKLIGTLSE 1420 KDMSMLEERI 1430 KRSAKRPSAA 1440 PIKQVEEKPQ 1450 RTQSMSSNAN 1460 MLRKGPAEDM 1470 SSKLNQARSM 1480 SGHPEAAQMV 1490 RREFQLDLDE 1500 IENDNGTVRC 1510 EMPELVQHKL 1520 DDIFEPVLIP 1530 EPKIRAVSPH 1540 FDDMHSNTAS 1550 TINFIISQVA 1560 SGDINTSIQA 1570 LTQIDEVLRQ 1580 EDKAEAMSGH 1590 IDQFLIATFM 1600 QLRLIYNTHM 1610 ADEKLEKDEI 1620 IKLYSCIIGN 1630 MISLFQIESL 1640 AREASTGVLK 1650 DLMHGLITLM 1660 LDSRIEDLEE 1670 GQQVIRSVNL 1680 LVVKVLEKSD 1690 QTNILRYILT 1700 ASDFYHLTMI 1710 DNKNESELEA 1720 HLCRMMKHSM 1730 DQTGSKSDKE 1740 TEKGASRIDE 1750 KSSKAKVNDF 1760 LAEIFKKIGS 1770 KENTKEGLAE 1780 LYEYKKKYSD 1790 ADIEPFLKNS 1800 SQFFQSYVER 1810 GLRVIEMERE 1820 GKGRIPTSTG 1830 ISPQMEVTCV 1840 PPPTSTVSSI 1850 GNTNGEEVGP 1860 SVYLERLKIL 1870 RQRCGLDNTK 1880 VRLLRCCGAG 1890 RAGAGRWGSR 1900 PALARVGPAP 1910 HPDAPGQCLF 1920 SRQQDDRPPL 1930 TSLLSKPAVP 1940 PVASSTDMLH 1950 SKLSQLRESR 1960 EQHQHSDLDS 1970 NQTHPSGTMT 1980 TSSSSTANID 1990 DLKKRLERIK SSRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0061863 microtubule plus end polymerase activity
Molecular Function GO:0051010 microtubule plus-end binding
Biological Process GO:0051301 cell division
Biological Process GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity
Biological Process GO:0046785 microtubule polymerization
Biological Process GO:0007051 spindle organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.