Overview
| Uniprot ID | A0A287A4R9 |
| Protein Name | Cytoskeleton-associated protein 5 |
| Gene Name | CKAP5 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1128 |
KPDPKKAKALGVSSK |
| 1135 |
KALGVSSKAKTAQGK |
| 1369 |
PTPGKALKEIAIHIG |
| 354 |
LAVGLRKKFGQYAGH |
| 496 |
KIKECSEKVELIHGK |
| 530 |
ASGAAGDKDTKDVSA |
| 559 |
GGPPKKGKPAAQGGT |
Function
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments
Protein Sequence
10
MGDDSEWMKL
20
PVDQKCEHKL
30
WKARLSGYEE
40
ALKIFQKVKD
50
EKSPEWSKFL
60
GLIKKFVTDS
70
NAVVQLKGLE
80
AALVYVENAH
90
VAGKTTGEVV
100
SGVVSKVFNQ
110
PKAKAKELGI
120
EICLMYIEIE
130
KGEAVQEELL
140
KGLDNKNPKI
150
IVACIETLRK
160
ALSEFGSKII
170
LLKPIIKVLP
180
KLFESREKAV
190
RDEAKLIAVE
200
IYRWIRDALR
210
PPLQNINSVQ
220
LKELEEEWVK
230
LPTGAPKPSR
240
FLRSQQELEA
250
KLEQQQSAGG
260
DAEGGGDDGD
270
EVPQIDAYEL
280
LEAVEILSKL
290
PKDFYDKIEA
300
KKWQERKEAL
310
EAVEVLVKNP
320
KLEAGDYADL
330
VKALKKVVGK
340
DTNVMLVALA
350
AKCLTGLAVG
360
LRKKFGQYAG
370
HVVPTILEKF
380
KEKKPQVVQA
390
LQEAIDAIFL
400
TTTLQNISED
410
ILAVMDNKNP
420
TIKQQTSLFI
430
ARSFRHCTAS
440
TLPKSLLKPF
450
CAALLKHIND
460
SAPEVRDAAF
470
EALGTALKVV
480
GEKAVNPFLA
490
DVDKLKLDKI
500
KECSEKVELI
510
HGKKAGLAAD
520
KKEVKPVPGR
530
TAASGAAGDK
540
DTKDVSAPKP
550
GPLKKAPATK
560
PGGPPKKGKP
570
AAQGGTGSTG
580
TKNKKGLETK
590
EIVEPELSIE
600
VCEEKASAVL
610
PAPCIQLLDS
620
SNWKERLACM
630
EEFQKAVELM
640
DRTEMPCQAL
650
VRMLAKKPGW
660
KETNFQVMQM
670
KLHIVALIAQ
680
KGNFSKTSAQ
690
IVLDGLVDKI
700
GDVKCGNNAK
710
EALTAIAEAC
720
MLPWTAEQVM
730
SMAFSQKNPK
740
NQSETLNWLS
750
NAIKEFGFSG
760
LNVKAFISNV
770
KTALAATNPA
780
VRTSAITLLG
790
VMYLYVGPSL
800
RMFFEDEKPA
810
LLSQIDAEFE
820
KMQGQNPPAP
830
TRGISKHSTS
840
GTDEGEDGDE
850
PDDGGNDVVD
860
LLPRTEISDK
870
ITSELVSKIG
880
DKNWKIRKEG
890
LDEVAGIINE
900
AKFIQPNIGE
910
LPTALKGRLN
920
DSNKILVQQT
930
LNILQQLAVA
940
MGPNIKQHVK
950
NLGIPIITVL
960
GDSKNNVRAA
970
ALATVNAWAE
980
QTGMKEWLEG
990
EDLSEELKKE
1000
NPFLRQELLG
1010
WLAEKLPTLR
1020
STPTDLILCV
1030
PHLYSCLEDR
1040
NGDVRKKAQD
1050
ALPFFMMHLG
1060
YEKMAKATGK
1070
LKPTSKDQVL
1080
AMLEKAKANM
1090
PAKPAAPAKA
1100
TSKPVGGSAP
1110
AKFQPTSAPV
1120
EDSVSGTIEP
1130
KPDPKKAKAL
1140
GVSSKAKTAQ
1150
GKKVPSKTTL
1160
KDDEDKSGPI
1170
FILVPNGKEQ
1180
RMRDEKSLKV
1190
LKWNFTTPRD
1200
EYIEQLKTQM
1210
SSCVAKWLQD
1220
EMFHSDFQHH
1230
NKALAVMVDH
1240
LESEKEGVIG
1250
CLDLILKWLT
1260
LRFFDTNTSV
1270
LMKALEYLKL
1280
LFTLLSEEEY
1290
HLTENEASSF
1300
IPYLILKVGE
1310
PKDVIRKDVR
1320
AILNRMCLVY
1330
PASKMFPFIM
1340
EGTKSKNSKQ
1350
RAECLEELGC
1360
LVESYGMNVC
1370
QPTPGKALKE
1380
IAIHIGDRDN
1390
AVRNAALNTI
1400
VTVYNVHGDQ
1410
VFKLIGTLSE
1420
KDMSMLEERI
1430
KRSAKRPSAA
1440
PIKQVEEKPQ
1450
RTQSMSSNAN
1460
MLRKGPAEDM
1470
SSKLNQARSM
1480
SGHPEAAQMV
1490
RREFQLDLDE
1500
IENDNGTVRC
1510
EMPELVQHKL
1520
DDIFEPVLIP
1530
EPKIRAVSPH
1540
FDDMHSNTAS
1550
TINFIISQVA
1560
SGDINTSIQA
1570
LTQIDEVLRQ
1580
EDKAEAMSGH
1590
IDQFLIATFM
1600
QLRLIYNTHM
1610
ADEKLEKDEI
1620
IKLYSCIIGN
1630
MISLFQIESL
1640
AREASTGVLK
1650
DLMHGLITLM
1660
LDSRIEDLEE
1670
GQQVIRSVNL
1680
LVVKVLEKSD
1690
QTNILRYILT
1700
ASDFYHLTMI
1710
DNKNESELEA
1720
HLCRMMKHSM
1730
DQTGSKSDKE
1740
TEKGASRIDE
1750
KSSKAKVNDF
1760
LAEIFKKIGS
1770
KENTKEGLAE
1780
LYEYKKKYSD
1790
ADIEPFLKNS
1800
SQFFQSYVER
1810
GLRVIEMERE
1820
GKGRIPTSTG
1830
ISPQMEVTCV
1840
PPPTSTVSSI
1850
GNTNGEEVGP
1860
SVYLERLKIL
1870
RQRCGLDNTK
1880
VRLLRCCGAG
1890
RAGAGRWGSR
1900
PALARVGPAP
1910
HPDAPGQCLF
1920
SRQQDDRPPL
1930
TSLLSKPAVP
1940
PVASSTDMLH
1950
SKLSQLRESR
1960
EQHQHSDLDS
1970
NQTHPSGTMT
1980
TSSSSTANID
1990
DLKKRLERIK
SSRK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0000922 |
spindle pole |
| Molecular Function |
GO:0061863 |
microtubule plus end polymerase activity |
| Molecular Function |
GO:0051010 |
microtubule plus-end binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0030951 |
establishment or maintenance of microtubule cytoskeleton polarity |
| Biological Process |
GO:0046785 |
microtubule polymerization |
| Biological Process |
GO:0007051 |
spindle organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.