Search Results
Overview
| Uniprot ID | A0A287A518 |
|---|---|
| Protein Name | Prohibitin |
| Gene Name | PHB1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 178 | RARFVVEKAEQQKKA |
| 184 | EKAEQQKKAAIISAE |
Function
In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells
Protein Sequence
10
MAAKVFESIG
20
KFGLALAVAG
30
GVVNSALYNV
40
DAGHRAVIFD
50
RFRGVQDIVV
60
GEGTHFLIPW
70
VQNVNITLRI
80
LFRPVASQLP
90
RIFTSIGEDY
100
DERVLPSITT
110
EILKSVVARF
120
DAGELITQRE
130
LVSRQVSDDL
140
TERAATFGLI
150
LDDVSLTHLT
160
FGKEFTEAVE
170
AKQVAQQEAE
180
RARFVVEKAE
190
QQKKAAIISA
200
EGDSKAAELI
210
ANSLATAGDG
220
LIELRKLEAA
230
EDIAYQLSRS
240
RNITYLPAGQ
SVLLQLPQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Biological Process | GO:0071897 | DNA biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.