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Overview

Uniprot IDA0A287A547
Protein NameExportin-T
Gene NameXPOT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
629 TPLMEKFKILLEKLM

Function

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Protein Sequence

10 MDEQALLGLN 20 PNADSDFRQR 30 ALAYFEQLKI 40 SPDAWQVCAE 50 ALAQRTYSDD 60 HIKFFCFQVL 70 EHQVKYKYSE 80 LTTIQQQLIR 90 ETLISWLQAQ 100 MLNPQAEKTF 110 IRNKAAQVFA 120 LLFVTEYLTK 130 WPKFFFDILS 140 VVDLNPRGVD 150 LYLRILMAID 160 SELVDRDVVH 170 TSEEARRNTL 180 IKDTMREQCI 190 PNLVESWYQI 200 LQNYQYTNSE 210 VTCQCLEVVG 220 AYVSWIDLSL 230 IANDRFINML 240 LGHMSIEVLR 250 EEACDCLFEI 260 VNKGMDPVDK 270 MKLVESLCQV 280 LQSAGFFSID 290 QEEDVDFLAR 300 FSKLVNGMGQ 310 SLIVSWTKLI 320 KNGDIKNAQE 330 ALQAIETKVA 340 LMLQLLIHED 350 DDISSNIIGF 360 CYDYLHILKQ 370 LTVLSDQQKA 380 NVEAIMLAVM 390 KKLTYDEEYN 400 FENEGEDEAM 410 FVEYRKQLKL 420 LLDRLAQVSP 430 ELLLASVRRV 440 FSSTLQNWQT 450 TRFMEVEVAI 460 RLLYMLAEAL 470 PVSHGAHFSG 480 DVSKASALQD 490 MMRTLVTSGV 500 SSYQHTSVTL 510 EFFETVVRYE 520 KFFTVEPQHI 530 PCVLMAFLDH 540 RGLRHNSAKV 550 RSRTAYLFSR 560 FVKSLNKQMN 570 PFIEDILNRI 580 QDLLELTPPE 590 NGYQSLLSSD 600 DQLFIYETAG 610 VLIVNSEYPA 620 ERKQALMRNL 630 LTPLMEKFKI 640 LLEKLMLAQD 650 EERQASLADC 660 LNHAVGFASR 670 TSKAFSNKQT 680 VKQCGCSEVY 690 LDCLQTFLPA 700 LSCPLQKDIL 710 RSGVRTFLHR 720 MIICLEEEVL 730 PFIPSASEHM 740 LKDCEAKDLQ 750 EFIPLINQIT 760 AKFKIQVSPF 770 LQQMFMPLLH 780 AIFEVLLRPA 790 EENDQSAALE 800 KQMLRRSYFA 810 FLQTVTGSGM 820 SEVIANQGAE 830 NVERVLITVI 840 QGAVEYPDPI 850 AQKTCFIILS 860 KLVELWGGKD 870 GPVGFADFVY 880 KHIVPACFLA 890 PLKQTFDLAD 900 AQTVLALSEC 910 AVTLKTIHLK 920 RGPECVQYLQ 930 QEYLPSLQVA 940 PEIIQEFCQA 950 LQQPDAKVFK 960 NYLKVGIWKS SFS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0071528 tRNA re-export from nucleus

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.