Overview
| Uniprot ID | A0A287A5A2 |
|---|
| Protein Name | Transforming growth factor beta-1-induced transcript 1 protein |
|---|
| Gene Name | TGFB1I1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 228 |
GLCGSCNKPIAGQVV |
| 435 |
FCLRPLTKGSFQERA |
Function
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity
Protein Sequence
10
MEDLDALLSD
20
LETTTSHMPR
30
SGALKERPPE
40
PLTSPLPQMG
50
SGESSGASGD
60
KDHLYSTVCK
70
PRSPKPAAPA
80
APPFSSSCGV
90
LGTGLCELDR
100
LLQELNATQF
110
NITDEIMSQF
120
PSSKESAGEK
130
KEDPSEDKKR
140
PSPPPSPTPV
150
LPKPSATSAT
160
LELDRLMASL
170
SDFRVQNHLP
180
ASGPTQPAVP
190
SSVNEGSPSP
200
PGPTSQGSLD
210
TMLGLLQSDL
220
SRRGVPTQAK
230
GLCGSCNKPI
240
AGQVVTALGR
250
AWHPEHFVCG
260
GCSTALGGSS
270
FFEKDGAPFC
280
PECYFERFSP
290
RCGLCNQPIR
300
HKMVTALGTH
310
WHPEHFCCVS
320
CGEPFGDEGF
330
HEREGRPYCR
340
RDFLQLFAPR
350
CQGCQGPILD
360
NYISALSALW
370
HPDCFVCREC
380
FAPFSGGSFF
390
EHEGRPLCEN
400
HFHARRGSLC
410
ATCGLPVTGR
420
CVSALGRRFH
430
PDHFTCTFCL
440
RPLTKGSFQE
450
RAGKPYCQPC
FLKLFG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.