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Overview

Uniprot ID	A0A287A5W2
Protein Name	Nipped-B protein
Gene Name	NIPBL
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
802	SERAEALKQRPDGRS

Function

Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner. Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others

Protein Sequence

10 MNGDMPHVPI 20 TTLAGIASLT 30 DLLNQLPLPS 40 PLPATTTKSL 50 LFNARIAEEV 60 NCLLACRDDN 70 LVSQLVHSLN 80 QVSTDHIELK 90 DNLGSDDPEG 100 DIPVLLQAVL 110 ARSPNVFREK 120 SMQNRYVQSG 130 MMMSQYKLSQ 140 NSMHSSPASS 150 NYQQTTISHS 160 PSSRFVPPQT 170 SSGNRFMPQQ 180 NSPVPSPYAP 190 QSPAGYMPYS 200 HPSSYTTHPQ 210 MQQASVSSPI 220 VAGGLRNLHD 230 NKVSGSLSGN 240 SANHHADNPR 250 HGSSDDYLHM 260 VHRLSSDDGD 270 SSTMRNAASF 280 PLRSPQPVCS 290 PAGSDGTPKG 300 SRPPLILQSQ 310 SLPCSSPRDV 320 PPDILLDSPE 330 RKQKKQKKMK 340 LGKDEKDQSE 350 KAAMYDIISS 360 PSKDSTKLTL 370 RLSRVRSSDM 380 DQQEDMLSGM 390 ENSNVSENDI 400 PFNVQYPGQT 410 SKTPITPQDV 420 NRPLNAAQCL 430 SQQEQTAFLP 440 ANQVPVLQQN 450 TSVATKQPQT 460 SVVQNQQQVS 470 QQGPIYDEVE 480 LDALAEIERI 490 ERESAIERER 500 FSKEVQDKDK 510 PLKKRKQDSY 520 PQEAGGATGG 530 NRPASQETGS 540 TGNGSRPALM 550 VSIDLHQAGR 560 VDSQASVTQD 570 SDSIKKPEEI 580 KQCNDAPISV 590 LQEDIIGNLK 600 STPENHPETP 610 KKKSDPELSK 620 NEMKQNESRL 630 AESKPNENRL 640 VETKSSESKL 650 DTKIEIQTEE 660 PKQNESRTIE 670 SKQNESTTAE 680 PKQNENRLSD 690 TKPNDNKQNN 700 GRSETAKSRP 710 ETPKQKGESR 720 PETPKQKSEG 730 RPETPKQKGD 740 GRPETPKQKG 750 EGRPETPKQK 760 NEGRPETPKH 770 RHENRRDPGK 780 PSTEKKPEMS 790 KHKQDIKSDS 800 PRLKSERAEA 810 LKQRPDGRSV 820 SESLRRDHDS 830 KQKSDDRSES 840 ERHRGDQSRV 850 RRPETLRSSS 860 RNEHGIKSDG 870 SKPDKLERKH 880 RHESGDSRER 890 LSSGEQKSRP 900 DSPRVKQGDS 910 NKSRPDKPGF 920 KSPNSKDDKR 930 TEGNKSKIDS 940 NKTHPDNKAE 950 FPSYLLGGRS 960 GALKNFVIPK 970 IKRDKDGNVT 980 QETKKMEMKG 990 EQKDKVEKMG 1000 LVEDLNKGAK 1010 PVVVLQKLSL 1020 DDVQKLIKDR 1030 EDKSRSSLKP 1040 IKNKPSKSNK 1050 GSIDQSVLKE 1060 LPPELLAEIE 1070 STMPLCERVK 1080 MNKRKRSTVN 1090 EKPKYAEISS 1100 DEDNDSDEAF 1110 ESSRKRHKKD 1120 DDKAWEYEER 1130 DRRSSGDHRR 1140 SGHSHEGRRS 1150 SGGGRYRNRS 1160 PSDSDMEDYS 1170 PPPSLSEVAR 1180 KMKKKEKQKK 1190 RKAYEPKLTP 1200 EEMMDSSTFK 1210 RFTASIENIL 1220 DNLEDMDFTA 1230 FGDDDEIPQE 1240 LLLGKHQLNE 1250 LGSESAKIKA 1260 MGIMDKLSTD 1270 KTVKVLNILE 1280 KNIQDGSKLS 1290 TLLNHNNDTE 1300 EEERLWRDLI 1310 MERVTKSADA 1320 CLTTINIMTS 1330 PNMPKAVYIE 1340 DVIERVIQYT 1350 KFHLQNTLYP 1360 QYDPVYRLDP 1370 HGGGLLSSKA 1380 KRAKCSTHKQ 1390 RVIVMLYNKV 1400 CDIVSSLSEL 1410 LEIQLLTDTT 1420 ILQVSSMGIT 1430 PFFVENVSEL 1440 QLCAIKLVTA 1450 VFSRYEKHRQ 1460 LILEEIFTSL 1470 ARLPTSKRSL 1480 RNFRLNSSDM 1490 DGEPMYIQMV 1500 TALVLQLIQC 1510 VVHLPSSEKD 1520 SNSEEDSNKK 1530 VDQDVVITNS 1540 YETAMRTAQN 1550 FLSIFLKKCG 1560 SKQGEEDYRP 1570 LFENFVQDLL 1580 STVNKPEWPA 1590 AELLLSLLGR 1600 LLVHQFSNKS 1610 TEMALRVASL 1620 DYLGTVAARL 1630 RKDAVTSKMD 1640 QGSIERILKQ 1650 VSGGEDEIQQ 1660 LQKALLDYLD 1670 ENTETDPSLV 1680 FSRKFYIAQW 1690 FRDTTLETEK 1700 AMKSQKDEES 1710 SEGTHHAKEV 1720 ETTGQIMHRA 1730 ESRKKFLRSI 1740 VKTTPSQFST 1750 LKMNSDTVDY 1760 DDACLIVRYL 1770 ASMRPFAQSF 1780 DIYLTQILRV 1790 LGENAIAVRT 1800 KAMKCLSEVV 1810 AVDPSILARL 1820 DMQRGVHGRL 1830 MDNSTSVREA 1840 AVELLGRFVL 1850 CRPQLAEQYY 1860 DMLIERILDT 1870 GISVRKRVIK 1880 ILRDICIEQP 1890 TFPKITEMCV 1900 KMIRRVNDEE 1910 GIKKLVNETF 1920 QKLWFTPTPH 1930 NDKEAMTRKI 1940 LNITDVVAAC 1950 RDTGYDWFEQ 1960 LLQNLLKSEE 1970 DSSYKPVKKA 1980 CTQLVDNLVE 1990 HILKYEESLA 2000 DSDNKGVNSG 2010 RLVACITTLF 2020 LFSKIRPQLM 2030 VKHAMTMQPY 2040 LTTKCSTQND 2050 FMVICNVAKI 2060 LELVVPLMEH 2070 PSETFLATIE 2080 EDLMKLIIKY 2090 GMTVVQHCVS 2100 CLGAVVNKVT 2110 QNFKFVWACF 2120 NRYYGAISKL 2130 KSQHQEDPNN 2140 TSLLTNKPAL 2150 LRSLFTVGAL 2160 CRHFDFDLED 2170 FKGNSKVNIK 2180 DKVLELLMYF 2190 TKHSDEEVQT 2200 KAIIGLGFAF 2210 IQHPSLMFEQ 2220 EVKNLYNNIL 2230 SDKKSSVNLK 2240 IQVLKNLQTY 2250 LQEEDTRMQQ 2260 ADRDWKKVAK 2270 QEDLKEMGDV 2280 SSGMSSSIMQ 2290 LYLKQVLEAF 2300 FHTQSSVRHF 2310 ALNVIALTLN 2320 QGLIHPVQCV 2330 PYLIAMGTDP 2340 EPAMRNKADQ 2350 QLVEIDKKYA 2360 GFIHMKAVAG 2370 MKMSYQVQQA 2380 INTCLKDPVR 2390 GFRQDESSSA 2400 LCSHLYSMIR 2410 GNRQHRRAFL 2420 ISLLNLFDDT 2430 ASMVKDKRKE 2440 RKSSPSKENE 2450 SSESEEEVSR 2460 PRKSRKRVDS 2470 DSDSDSEDDI 2480 NSVMKCLPEN 2490 SAPLIEFANV 2500 SQGILLLLML 2510 KQHLKNLCGF 2520 SDSKIQKYSP 2530 SESAKVYDKA 2540 INRKTGVHFH 2550 PKQTLDFLRS 2560 DMANSKITED 2570 VKRSIVKQYL 2580 DFKLLMEHLD 2590 PDEEEEEGEV 2600 SASTNARNKA 2610 ITSLLGGGSP 2620 KNNAAAETED 2630 DESDGEDRGG 2640 GTSGVRRRRS QRISQRITH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0061775	cohesin loader activity
Biological Process	GO:0140588	chromatin looping
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0048562	embryonic organ morphogenesis
Biological Process	GO:0007507	heart development
Biological Process	GO:0048638	regulation of developmental growth
Biological Process	GO:0010468	regulation of gene expression

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.