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Overview

Uniprot ID	A0A287A5X5
Protein Name	Coatomer subunit gamma
Gene Name	COPG2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
151	KISYDVVKRWVNEAQ
791	QPCERSDKVPENKNS

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 MIKKFDKKDE 20 ESGSGSNPFR 30 HLEKSAVLQE 40 ARIFNETPIN 50 PRRCLHILTK 60 ILYLLNQQTL 70 RRMCYLTIKE 80 MATISEDVII 90 VTSSLTKDMT 100 GKEDVYRGPA 110 IRALCRITDG 120 TMLQAIERYM 130 KQAIVDKVSS 140 VSSSALVSSL 150 HMMKISYDVV 160 KRWVNEAQEA 170 ASSDNIMVQY 180 HALGVLYHLK 190 KNDRLAVSKM 200 LNKFTKCGLK 210 SQFAYCMLIR 220 IASRLLKENE 230 EGHESPVFDF 240 IESCLRNKHE 250 MVIYEAASAI 260 IHLPNCSARE 270 LAPAVSVLQL 280 FCSSPKPALR 290 YAAVRTLNKV 300 AMKHPSAVTA 310 CNLDLENLIT 320 DSNRSIATLA 330 ITTLLKTGSE 340 SSVDRLMKQI 350 SSFVSEISDE 360 FKVVVVQAIS 370 ALCQKYPRKH 380 SVMMTFLSNM 390 LRDDGGFEYK 400 RAIVDCIINI 410 VEENPESKEA 420 GLAHLCEFIE 430 DCEHTVLATK 440 ILHLLGKEGP 450 RTPVPSKYIR 460 FIFNRVVLEN 470 EAVRAAAVSA 480 LAKFGAQNEN 490 LLPSILVLLQ 500 RCMMDTDDEV 510 RDRATFYLNV 520 LQQRQMALNA 530 TYIFNGLTVS 540 VPGMEKALHQ 550 YTLEPSEKPF 560 DMKSIPLAMA 570 PVFEQKSEIT 580 LVATKPEKLA 590 PSRQDIFQEQ 600 LAAIPEFMNL 610 GPLFKSSEPV 620 QLTEAETEYF 630 VRCVKHMFTN 640 HVVFQFDCTN 650 TLNDQLLEKV 660 TVQVEPSDSY 670 EVLCCIPAAS 680 LPYNQPGICY 690 TLVRLPDDDS 700 IAAAGTFSCT 710 MKFTVRDCDP 720 DTGVPAEEGY 730 DDEYVLEDLE 740 VTVSDHIQKV 750 LKPNFAAAWE 760 EVGDTFEKEE 770 TFALSSTKTL 780 EEAVSNIITF 790 LGMQPCERSD 800 KVPENKNSHA 810 LYLAGVYRGG 820 CDLLVRSRLA 830 LADGVTMQVT 840 VRSKEGTPVD VILASVG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030126	COPI vesicle coat
Cellular Component	GO:0000139	Golgi membrane
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0016192	vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.