Overview
| Uniprot ID | A0A287A699 |
|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein K |
|---|
| Gene Name | HNRNPK |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 163 |
AGGIIGVKGAKIKEL |
| 179 |
ENTQTTIKLFQECCP |
| 198 |
RVVLIGGKPDRVVEC |
| 34 |
MEEEQAFKRSRNTDE |
| 405 |
LAGSIIGKGGQRIKQ |
| 422 |
HESGASIKIDEPLEG |
| 52 |
LRILLQSKNAGAVIG |
| 60 |
NAGAVIGKGGKNIKA |
Function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation
Protein Sequence
10
METEQPEETF
20
PNTETNGEFG
30
KRPAEDMEEE
40
QAFKRSRNTD
50
EMVELRILLQ
60
SKNAGAVIGK
70
GGKNIKALRT
80
DYNASVSVPD
90
SSGPERILSI
100
SADIETIGEI
110
LKKIIPTLEE
120
GLQLPSPTAT
130
SQLPLESDAV
140
ECLNYQHYKG
150
SDFDCELRLL
160
IHQSLAGGII
170
GVKGAKIKEL
180
RENTQTTIKL
190
FQECCPQSTD
200
RVVLIGGKPD
210
RVVECIKIIL
220
DLISESPIKG
230
RAQPYDPNFY
240
DETYDYGGFT
250
MMFDDRRGRP
260
VGFPMRGRGG
270
FDRMPPGRGG
280
RPMPPSRRDY
290
DDMSPRRGPP
300
PPPPGRGGRG
310
GSRARNLPLP
320
PPPPPRGGDL
330
MAYDRRGRPG
340
DRYDGMVGFS
350
ADETWDSAID
360
TWSPSEWQMA
370
YEPQVEYQSD
380
YSYAGGRGSY
390
GDLGGPIITT
400
QVTIPKDLAG
410
SIIGKGGQRI
420
KQIRHESGAS
430
IKIDEPLEGS
440
EDRIITITGT
450
QDQIQNAQYL
460
LQNSVKQYSG
KFF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0002102 |
podosome |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.