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Overview

Uniprot ID	A0A287A6D5
Protein Name	Melanoma inhibitory activity protein 2
Gene Name	MIA2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
870	VEQVLCDKENQIKSL

Function

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis. Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites

Protein Sequence

10 MAELGIHRIL 20 LLVISLTKCL 30 EGTKRLADFK 40 KCGDLECETL 50 ISRVLAIRDY 60 RGPDCRYLNF 70 TKGEEISVYI 80 KLAGEKEDLW 90 AGSKGKDFGY 100 FPRDAVQIEE 110 VFISEEVQIS 120 TKESDFFCLL 130 GISYTFENED 140 IELNIDHSDN 150 IYLYEEDEDP 160 KSNVYESDFQ 170 IEPGFFSTSE 180 GTLFEDQFPA 190 SEAPEAIRST 200 SESKDWEAAE 210 VRSVEEHPLP 220 EVDHVPPSSA 230 VPEVKGWFGF 240 RKDQAEGETF 250 ESVIEPLQES 260 SLLSRKIAVE 270 DENDPEKLNN 280 DEPQTEHKQE 290 PESEVDSMPT 300 KQSELVSESE 310 HYPQDTGWFG 320 GRFTSYFGFR 330 GEDTGLELLS 340 KESNPPLQDV 350 PNSISSEEES 360 TVPCTETLTE 370 KEDTLTNDSS 380 ILKPRWFEFG 390 FAMLGIAYAN 400 EDKIISDDGK 410 NEESGGEDKH 420 GPPPTSEFDP 430 GEEQELKIMK 440 IVETESQIGK 450 EGALEKTDDS 460 DTLPYFKKFL 470 GNFENSWNFK 480 NIPKETELPF 490 PKKTLDENNV 500 GENDETEEFS 510 LENYPTDNTE 520 DMTLESRYSQ 530 SDMNSKIELP 540 MIIHEEVHFK 550 TLSSENNDEN 560 SKTSLDTERS 570 TMVEIDTSVE 580 NTLPNSQIFS 590 TDYSLSSQNY 600 LDQKEDASVG 610 QILKYLFQID 620 VFDFLNPAFS 630 PIVILTGRVV 640 AALPEDMNFH 650 GFPWEVVICA 660 TIVGLFAVVL 670 FLWRSFRSVR 680 SRLYVGREKK 690 LAAELSALIE 700 EKCKLLEKFS 710 LVQKEYEGLE 720 SSLKDASFEK 730 ESTEAQSLEF 740 VEGSQISEAF 750 CGKLINSQSE 760 LEDEILFLEK 770 ELREEKSKHS 780 EQDELMVDIS 790 KRIQSLEDES 800 KSLKSQVSEA 810 KTTFKIFQMN 820 EERLKISIKD 830 ALSENSQLQE 840 SQKQLLQEAE 850 EWRERVNELN 860 KQKMTFEDSR 870 AHVEQVLCDK 880 ENQIKSLTER 890 LLKMKDWSAV 900 LGEDITNDDN 910 LDLEMKNDSE 920 NDTLPKGTLK 930 KLIHAAKLKA 940 SLKTLEGERN 950 QIYTQLSEVD 960 KTKEDLTECI 970 ENLQTEQASL 980 QSENTQFENE 990 IQKLQQKLKV 1000 MTELYQENEM 1010 TLHRKLTVEE 1020 NYRLEKEEKL 1030 SKADEKISHA 1040 VEELETYRKR 1050 ARDLEEELER 1060 TIHSYQGQSI 1070 SHEKKAHDNW 1080 LAARNAERNL 1090 NDLRKENAYS 1100 RQKLTETELK 1110 FELLEKDPYA 1120 LDVPNTAFGR 1130 EHSPYGPSPL 1140 GRPSPETRAF 1150 LSPPTLLEGP 1160 LRLSPLLPGG 1170 GGRGSRGPGN 1180 PLDHPITNER 1190 GDSSADWLID 1200 PHRAPSDTGS 1210 LSPPWEQDRR 1220 MMIPPSGQPY 1230 PDPVFPPQRQ 1240 DRFYSNSGRL 1250 SGPAELRSFN 1260 MPSLDKVDGP 1270 VSSEMESNRT 1280 DGKDDLGNLN 1290 VPDSSLPNES 1300 EATGPGFVPP 1310 PRPPVRGPLF 1320 PLDARGPFLR 1330 RGPPFPPPPP 1340 GSMYAAPRDY 1350 FPPRDFPGPP 1360 PPPFAMRSVY 1370 PPRGFPHYLP 1380 PRAGFFPPPP 1390 HPESRSEFPA 1400 GLIPPSNEPT 1410 TEHPEPQQET

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070971	endoplasmic reticulum exit site
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process	GO:0009306	protein secretion
Biological Process	GO:0035459	vesicle cargo loading

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.