Search Results
Overview
| Uniprot ID | A0A287A6N0 |
|---|---|
| Protein Name | Polypeptide N-acetylgalactosaminyltransferase |
| Gene Name | GALNT2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 405 | LRKKLSCKPFKWYLE |
| 490 | RAPGSLIKLQGCREN |
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism
Protein Sequence
10
MLGALTLGRA
20
LGAGSVLPRV
30
SPQEDWNEID
40
PIKKKDLHHS
50
NGDEKAQSME
60
TLPPGKVRWR
70
DFNQEAYVGG
80
TMVRSGQDPY
90
ARNKFNQVES
100
DKLRMDRAVP
110
DTRHDQCQRK
120
QWRVDLPATS
130
VVITFHNEAR
140
SALLRTVVSV
150
LKKSPPHLIK
160
EIILVDDYSN
170
DPEDGALLGK
180
IEKVRVLRND
190
RREGLMRSRV
200
RGADAAQAKV
210
LTFLDSHCEC
220
NEHWLEPLLE
230
RVAEDRTRVV
240
SPIIDVINMD
250
NFQYVGASAD
260
LKGGFDWNLV
270
FKWDYMTPEQ
280
RRARQGNPVA
290
PIKTPMIAGG
300
LFVMDKFYFE
310
ELGKYDMMMD
320
VWGGENLEIS
330
FRVWQCGGSL
340
EIIPCSRVGH
350
VFRKQHPYTF
360
PGGSGTVFAR
370
NTRRAAEVWM
380
DEYKNFYYAA
390
VPSARNVPYG
400
NIQSRLELRK
410
KLSCKPFKWY
420
LENVYPELRV
430
PDHQDIAFGA
440
LQQGTNCLDT
450
LGHFADGVVG
460
VYECHNAGGN
470
QEWALTKEKS
480
VKHMDLCLTV
490
VDRAPGSLIK
500
LQGCRENDSR
510
QKWEQIEGNS
520
KLRHVGSNLC
530
LDSRAAKNGG
540
LSVEVCGPAL
550
SQQWKFSLNL
QQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0032580 | Golgi cisterna membrane |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity |
| Biological Process | GO:0002639 | positive regulation of immunoglobulin production |
| Biological Process | GO:0051604 | protein maturation |
| Biological Process | GO:0006493 | protein O-linked glycosylation |
| Biological Process | GO:0016266 | protein O-linked glycosylation via N-acetyl-galactosamine |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.