Search Results
Overview
| Uniprot ID | A0A287A6P1 |
|---|---|
| Protein Name | Gelsolin |
| Gene Name | GSN |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | GGVASGFKHVVPNEV |
| 191 | VQRLFQVKGRRVVRA |
| 243 | LKATQVSKGIRDNER |
| 336 | CFILDHGKDGKIFVW |
| 339 | LDHGKDGKIFVWKGK |
| 344 | DGKIFVWKGKQANTE |
| 358 | EERKAALKTASDFIS |
| 673 | RLFACSNKIGRFVIE |
| 726 | TEALTSAKRYIETDP |
Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis
Protein Sequence
10
MAPHRSALLG
20
ALVVALCALS
30
PPARAATASR
40
GAPQARAPQG
50
RVSPMRPSTM
60
VVEHPEFLKA
70
GKEPGLQIWR
80
VEKFDLVPVP
90
PNLYGDFFTG
100
DAYVILKTVQ
110
LRNGNLQYDL
120
HYWLGNECSQ
130
DESGAAAIFT
140
VQLDDYLNGR
150
AVQHREVQGF
160
ESATFLGYFK
170
SGLKYKKGGV
180
ASGFKHVVPN
190
EVAVQRLFQV
200
KGRRVVRATE
210
VPVSWESFNR
220
GDCFILDLGN
230
DIYQWCGSNS
240
NRYERLKATQ
250
VSKGIRDNER
260
SGRAHVHVSE
270
EDAEPAGMLQ
280
VLGPKPTLPE
290
GTEDTVKEDA
300
ANRKLAKLYK
310
VSNGAGTMTV
320
SLVADENPFA
330
QGALKSEDCF
340
ILDHGKDGKI
350
FVWKGKQANT
360
EERKAALKTA
370
SDFISKMNYP
380
KQTQVSVLPE
390
GGETPLFKQF
400
FKNWRDPDQV
410
DGPGLSYLSS
420
HIANVERVPF
430
DAATLHTSTA
440
MAAQHGMDDD
450
GTGQKQIWRI
460
EGSNKVPVDP
470
ATYGQFYGGD
480
SYIILYNYRH
490
GGRQGQIIYN
500
WQGAQSTQDE
510
VAASAILTAQ
520
LDEELGGTPV
530
QSRVVQGKEP
540
AHLMSLFGGK
550
PMIIYRGGTS
560
REGGQTAPAS
570
TRLFQVRASS
580
SGATRAVEVI
590
PKAGALNSND
600
AFVLKTPSAA
610
YLWVGTGASE
620
AEKTGAQELL
630
RVLRAQPVQV
640
AEGSEPDSFW
650
EALGGKAAYR
660
TSPRLKDKKM
670
DAHPPRLFAC
680
SNKIGRFVIE
690
EVPGELMQED
700
LATDDVMLLD
710
TWDQVFVWVG
720
KDSQEEEKTE
730
ALTSAKRYIE
740
TDPANRDRRT
750
PINVVKQGFE
760
PPSFVGWFLS
770
WDDNYWSVDP
780
LDRAIAELAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030478 | actin cap |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0016528 | sarcoplasm |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0045159 | myosin II binding |
| Molecular Function | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0030041 | actin filament polymerization |
| Biological Process | GO:0051014 | actin filament severing |
| Biological Process | GO:0008154 | actin polymerization or depolymerization |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
| Biological Process | GO:0086003 | cardiac muscle cell contraction |
| Biological Process | GO:0030031 | cell projection assembly |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0097284 | hepatocyte apoptotic process |
| Biological Process | GO:0046597 | host-mediated suppression of symbiont invasion |
| Biological Process | GO:0006911 | phagocytosis, engulfment |
| Biological Process | GO:0051127 | positive regulation of actin nucleation |
| Biological Process | GO:1902174 | positive regulation of keratinocyte apoptotic process |
| Biological Process | GO:1903923 | positive regulation of protein processing in phagocytic vesicle |
| Biological Process | GO:0031648 | protein destabilization |
| Biological Process | GO:1903903 | regulation of establishment of T cell polarity |
| Biological Process | GO:1903906 | regulation of plasma membrane raft polarization |
| Biological Process | GO:1903909 | regulation of receptor clustering |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0097017 | renal protein absorption |
| Biological Process | GO:0035994 | response to muscle stretch |
| Biological Process | GO:0014891 | striated muscle atrophy |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.