Overview
| Uniprot ID | A0A287A7D8 |
|---|
| Protein Name | Coatomer subunit epsilon |
|---|
| Gene Name | COPE |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 227 |
NRYLSQLKDAHRTHP |
| 242 |
FIKEYHAKENDFDRL |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors
Protein Sequence
10
MAPPAPGPAS
20
GGSGEVDELF
30
DVKNAFYIGS
40
YQQCINEAQR
50
VKPSSPERDV
60
ERDVFLYRAY
70
LAQRKFGVVL
80
DEIKPSSAPE
90
LQAIRMFAEY
100
LASDSRRMAM
110
TVQILLKLDR
120
LDLARKELKK
130
MQDQDEDATL
140
TQLATAWVNL
150
AVGGEKLQDA
160
YYIFQEMADK
170
CSSTLLLLNG
180
QAACHMAQGR
190
WEAAEGVLQE
200
ALDKDSSHPE
210
TLINLIVLSQ
220
HLGKPPEVTN
230
RYLSQLKDAH
240
RTHPFIKEYH
250
AKENDFDRLV
LQYAPSA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030663 |
COPI-coated vesicle membrane |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.