Search Results
Overview
| Uniprot ID | A0A287A8J7 |
|---|---|
| Protein Name | Ribonucleoside-diphosphate reductase |
| Gene Name | RRM1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 157 | LERSYLLKISGKVAE |
| 413 | YKDSCNRKSNQQNLG |
| 470 | TKLAEVTKVIVRNLN |
Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Protein Sequence
10
MHVIKRDGRQ
20
ERVMFDKITS
30
RIQKLCYGLN
40
MDFVDPAQIT
50
MKVIQGLYSG
60
VTTVELDTLA
70
AETAATLTTK
80
HPDYAILAAR
90
IAVSNLHKET
100
KKVFSDVMED
110
LFNYINPHNG
120
KHSPMVASTL
130
DIVLANKDRL
140
NSAIIYDRDF
150
SYNYFGFKTL
160
ERSYLLKISG
170
KVAERPQHML
180
MRVSVGIHKE
190
DIDAAIETYN
200
LLSEKWFTHA
210
SPTLFNAGTN
220
RPQLSSCFLL
230
SMKDDSIEGI
240
YDTLKQCALI
250
SKSAGGIGVA
260
VSCIRATGSY
270
IAGTNGNSNG
280
LVPMLRVYNN
290
TARYVDQGGN
300
KRPGAFAIYL
310
EPWHLDIFEF
320
LDLKKNTGKE
330
EQRARDLFFA
340
LWIPDLFMKR
350
VETNQDWSLM
360
CPNECPGLDE
370
VWGEEFEKLY
380
ESYERQGHVR
390
KVVKAQQLWY
400
AIIESQTETG
410
TPYMLYKDSC
420
NRKSNQQNLG
430
TIKCSNLCTE
440
IVEYTSKDEV
450
AVCNLASLAL
460
NMYVTSEHTY
470
DFTKLAEVTK
480
VIVRNLNKII
490
DINYYPIPEA
500
SLSNKRHRPI
510
GIGVQGLADA
520
FILMRYPFES
530
PEAQLLNKQI
540
FETIYYGALE
550
ASCDLAKEYG
560
PYETYEGSPV
570
SKGILQYDMW
580
NVTPTDLWDW
590
KLLKEKIAKY
600
GIRNSLLIAP
610
MPTASTAQIL
620
GNNESIEPYT
630
SNIYTRRVLS
640
GEFQIVNPHL
650
LKDLTERGLW
660
NEEMKNQIIA
670
CNGSIQSIPE
680
IPDDLKQLYK
690
TVWEISQKTV
700
LKMAAERGAF
710
IDQSQSLNIH
720
IAEPNYGKLT
730
SMHFYGWKQG
740
LKTGMYYLRT
750
RPAANPIQFT
760
LNKEKLKDKE
770
KVSKEEEKER
780
NTAAMVCSLE
790
NRDECLMCGS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005971 | ribonucleoside-diphosphate reductase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0097718 | disordered domain specific binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036175 | ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor |
| Molecular Function | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| Biological Process | GO:0009265 | 2'-deoxyribonucleotide biosynthetic process |
| Biological Process | GO:0009263 | deoxyribonucleotide biosynthetic process |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006264 | mitochondrial DNA replication |
| Biological Process | GO:0070318 | positive regulation of G0 to G1 transition |
| Biological Process | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| Biological Process | GO:0051290 | protein heterotetramerization |
| Biological Process | GO:0009185 | ribonucleoside diphosphate metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.