Search Results
Overview
| Uniprot ID | A0A287A8P3 |
|---|---|
| Protein Name | Erlin |
| Gene Name | ERLIN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 231 | LMESEKTKLLIAAQK |
| 238 | KLLIAAQKQKVVEKE |
| 326 | YLQLMKYKAIASNSK |
Function
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex
Protein Sequence
10
MAQLGAVVAV
20
AASFFCASLF
30
SAVHKIEEGH
40
IGVYYRGGAL
50
LTSTSGPGFH
60
LMLPFITSYK
70
SVCDCAVPAS
80
SNSGGVMIYF
90
DRIEVVNFLV
100
PHAGTSLSLQ
110
SHTHTHRPQH
120
QAPREGTVAV
130
SQNTVSPSLL
140
VLSLSFLSVY
150
DIVKNYTADY
160
DKALIFNKIH
170
HELNQFCSVH
180
TLQEVYIELF
190
DQIDENLKLA
200
LQQDLTSMAP
210
GLVIQAVRVT
220
KPNIPEAIRR
230
NYELMESEKT
240
KLLIAAQKQK
250
VVEKEAETER
260
KKALIEAEKV
270
AQVAEITYGQ
280
KVMEKETEKK
290
ISEIEDAAFL
300
AREKAKADAE
310
CYTAMKIAEA
320
NKLKLTPEYL
330
QLMKYKAIAS
340
NSKIYFGKDI
350
PNMFMDSAGS
360
LGKQFEGLTD
370
KLSFGLEDEP
LEAGTEEN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0008203 | cholesterol metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.