Search Results
Overview
| Uniprot ID | A0A287A8Y0 |
|---|---|
| Protein Name | U5 small nuclear ribonucleoprotein TSSC4 |
| Gene Name | TSSC4 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 331 | SRDHFRSKGHGPEAP |
Function
Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP
Protein Sequence
10
ARRGHGGLCH
20
QQPLPGPSSP
30
ARRCLRQPPA
40
ALAGVARPLD
50
AWLRRGQPWR
60
STPCLLTPSP
70
SVTRTRTLAC
80
PTLLRWKLSP
90
PGPPGAVVQP
100
FHLRGTSPTF
110
SQRSHDIFDH
120
LEGAAGRALP
130
SAAPAGPGHS
140
GGFKLPPLPS
150
RRPPAGARGR
160
ATQSPAPPRA
170
PPVPDYVAHP
180
ERWTKYSLED
190
VAEASEQSNR
200
AAALAFLGPQ
210
SLAAPGDYVP
220
SFNQDPSSCG
230
EGRVVFTKPA
240
RTSEARPERK
250
RGLRKAGEPG
260
RAAPGSPGTA
270
GGGDGPVELA
280
HLAGPGSPEA
290
AEEGSGPRGG
300
LVEVAVPEGL
310
APPGAAAGPS
320
PVETVGFHGS
330
KKRSRDHFRS
340
KGHGPEAPGG
AEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0005682 | U5 snRNP |
| Molecular Function | GO:0140313 | molecular sequestering activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.