Overview
| Uniprot ID | A0A287A9I5 |
|---|
| Protein Name | Glutaredoxin-2, mitochondrial |
|---|
| Gene Name | GLRX2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 150 |
LVHQCYLKKSKRKEF |
Function
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release
Protein Sequence
10
MYWRRAALAG
20
TRLVRRVSGS
30
TGRFGGAPGA
40
SASGMGNHTS
50
SSLGNTAAAP
60
VNQIQETISN
70
NCVVIFSKTS
80
CSYCTMAKKL
90
FHDMNVSYKV
100
VELDLLEYGS
110
QFQDALCTMT
120
GDRTVPRIFV
130
NGTFIGGAMD
140
THRLHQEGKL
150
LPLVHQCYLK
KSKRKEF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0051537 |
2 iron, 2 sulfur cluster binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.