Overview
| Uniprot ID | A0A287A9J3 |
|---|
| Protein Name | - |
|---|
| Gene Name | COPS7B |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 113 |
TAQQNKLKHLTIVSL |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Protein Sequence
10
MSHITRRPNK
20
RSQGQRMAGE
30
QKPSSNLLEQ
40
FILLAKGTSG
50
SALTALISQV
60
LEAPGVYVFG
70
ELLELANVQE
80
LAEGANAAYL
90
QLLNLFAYGT
100
YPDYIANKES
110
LPELSTAQQN
120
KLKHLTIVSL
130
ASRMKCIPYS
140
VLLRDLEMRN
150
LRELEDLIIE
160
AVYTDIIQGK
170
LDQRNQLLEV
180
DFCIGRDIRK
190
KDINNIVKTL
200
HEWCDGCEAV
210
LLGIEQQVLR
220
ANQYKENHSR
230
TQQQVEAEIA
240
CSQRGELDVS
250
PQNLIRAAIF
260
WLPTSRRHSK
270
PRRPLPRRRW
280
SSSWLNESVP
290
RTPSRGSPLR
RCPK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Biological Process |
GO:0010387 |
COP9 signalosome assembly |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.