Search Results
Overview
| Uniprot ID | A0A287A9L8 |
|---|---|
| Protein Name | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
| Gene Name | CNP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 162 | RLDCAQLKEKNHWQL |
| 164 | DCAQLKEKNHWQLSA |
| 255 | GVLHCTTKFCDYGKA |
| 275 | YAQQEVVKKSYSKAF |
Function
Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions
Protein Sequence
10
MHFQGFSRKS
20
QTFLPKIFFR
30
KMSSSGAKDK
40
PELQFPFLQD
50
EETVATLQEC
60
KTLFILRGLP
70
GSGKSTLAQV
80
IMDRYRDGTK
90
VVSADAYKIT
100
PGARGAFTEE
110
YKRLDEDLAA
120
CCRRDIRVLV
130
LDDTNHERER
140
LEQLFEMADQ
150
YQYQVVLVEP
160
KTAWRLDCAQ
170
LKEKNHWQLS
180
ADDLKKLKPG
190
LEKDFLPLYF
200
GWFLSRKSSE
210
SLRKAGQTFL
220
EELGNHKAFK
230
KELRHFGSGD
240
EPREKMELVA
250
YFGKRPPGVL
260
HCTTKFCDYG
270
KAAGAEEYAQ
280
QEVVKKSYSK
290
AFVLTISALF
300
VTPKTTGARV
310
ELSEQELALW
320
PNDVDKLSPS
330
DSLPRGSRAH
340
ITLGCAGDVE
350
AVQTGLDLLE
360
IVRQEKGGSR
370
GEEVGELSRG
380
KLYSLGNGRW
390
MLSLAKKMEV
400
RAIFTGYYGK
410
GKAVPTRGGR
420
KGGSFQSCAI
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043209 | myelin sheath |
| Molecular Function | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0009214 | cyclic nucleotide catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.