Search Results

Overview

Uniprot ID	A0A287AA01
Protein Name	CLIP-associating protein 1
Gene Name	CLASP2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1360	TIRALALKVLREILR
1511	KLLNLYIKRAQTGSG
240	ILSVCKDKSFDDEES

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRSMEYFS 20 AQVQQKDVGG 30 RLQVGQELLL 40 YLGVPGAIPD 50 LEENLGCLGK 60 TVDALTGWVG 70 SSNYRVSLMG 80 LEILSAFVDR 90 LSTRFKSYVA 100 MVIVALIDRL 110 GDAKDKVRDK 120 TQALILKLMD 130 QVAPPMYIWE 140 QLASGFKHKN 150 SQSREGVCLC 160 LIETLNVFGA 170 QPLVLSKLVP 180 HLCILFGDYN 190 SQVRDAATLA 200 IVEIYRHVGD 210 KVRMDLYKKG 220 IPPARLETIL 230 AKFDEVQNSG 240 GMILSVCKDK 250 SFDDEESVDG 260 NRPSSAASAF 270 KVPAPKTSGN 280 PVNSARKPGS 290 AGGPKVGAGA 300 SKEGGAGAVD 310 EDDFIKAFTD 320 VPSIQIYSSR 330 ELEETLNKIR 340 EILSDDKHDW 350 DQRANALKKI 360 RSLLVAGAAQ 370 YDCFFQHLRL 380 LDGALKLSAK 390 DLRSQVVREA 400 CITVAHLSTV 410 LGNKFDHGAE 420 AIVPTLFNLV 430 PNSAKVMATS 440 GCAAIRFIIR 450 HTHVPRLIPL 460 ITSNCTSKSV 470 PVRRRSFEFL 480 DLLLQEWQTH 490 SLERHAAVLV 500 ETIKKGIHDA 510 DAEARVEARK 520 TYMGLRNHFP 530 GEAETLYNSL 540 EPSYQKSLQT 550 YLKSSGSVAS 560 LPQSDRSSSS 570 SQESLNRPFS 580 SKWSTANPST 590 VAGRVSTGSS 600 KANSLPGSLQ 610 RSRSDIDVNA 620 AAGAKAHHAA 630 GQSVRSGRLG 640 AGALNPGSYA 650 SLGRVRAKLS 660 APLAGMGSAK 670 TDTRGRSRTK 680 MVSQSQPGSR 690 SGSPGRVLTT 700 TALSTVSSGV 710 QRVLVNSASA 720 QKRSKIPRSQ 730 GCSREASPSR 740 LSVARSSRIP 750 RPSVSQGCSR 760 EASRESSRDT 770 SPVRSFQPLA 780 SRHHSRSTGA 790 LYAPDVYGAS 800 GPGYGISQSS 810 RLSSSVSAMR 820 VLNTGSDVEE 830 AVADALKKPA 840 RRRYESYGMH 850 SDDDANSDAS 860 SACSERSYSS 870 RNGSIPTYMR 880 QTEDVAEVLN 890 RCASSNWSER 900 KEGLLGLQNL 910 LKNQRTLSRV 920 ELKRLCEIFT 930 RMFADPHGKV 940 FSMFLETLVD 950 FIQVHKDDLQ 960 DWLFVLLTQL 970 LKKMGADLLG 980 SVQAKVQKAL 990 DVTRESFPND 1000 LQFNILMRFT 1010 VDQTQTPSLK 1020 TVKPALRDQL 1030 HCFWSSKVKV 1040 AILKYIETLA 1050 KQMDPGDFIN 1060 SSETRLAVSR 1070 VITWTTEPKS 1080 SDVRKAAQSV 1090 LISLFELNTP 1100 EFTMLLGALP 1110 KTFQDGATKL 1120 LHNHLRNTGN 1130 GTQGSMGSPL 1140 TRPTPRSPAN 1150 WSSPLTSPTN 1160 TSQNTLSPSA 1170 FDYDTENMNS 1180 EDIYSSLRGV 1190 TEAIQNFSFR 1200 SQEDMNEPLK 1210 RESKKDDVDS 1220 MCGGPGMSDP 1230 RAGGDATDSS 1240 QTALDNKASL 1250 LHSMPAHSSP 1260 RSRDYNPYNY 1270 SDSISLFNKS 1280 ALKEAMFDDD 1290 ADQFPDDLSL 1300 DHSDLVAELL 1310 KELSNHNERV 1320 EERKIALYEL 1330 MKLTQEESFS 1340 VWDEHFKTIL 1350 LLLLETLGDK 1360 EPTIRALALK 1370 VLREILRHQP 1380 ARFKNYAELT 1390 VMKTLEAHKD 1400 PHKEVVRSAE 1410 EAASVLATSI 1420 SPEQCIKVLC 1430 PIIQTADYPI 1440 NLAAIKMQTK 1450 VIERVSKETL 1460 NLLLPEIMPG 1470 LIQGYDNSES 1480 SVRKACVFCL 1490 VAVHAVIGDE 1500 LKPHLSQLTG 1510 SKMKLLNLYI 1520 KRAQTGSGGG 1530 DPTTDVSGQS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0045180	basal cortex
Cellular Component	GO:0005813	centrosome
Biological Process	GO:0030010	establishment of cell polarity
Biological Process	GO:0040001	establishment of mitotic spindle localization
Biological Process	GO:0090307	mitotic spindle assembly
Biological Process	GO:0007026	negative regulation of microtubule depolymerization
Cellular Component	GO:0005881	cytoplasmic microtubule
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005815	microtubule organizing center
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0005876	spindle microtubule
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.