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Overview

Uniprot IDA0A287AAA2
Protein NameNardilysin
Gene NameNRDC
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
989 PGAHHLCKVRALNKG

Function

Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH)

Protein Sequence

10 MLRRVTVAAV 20 SATGRKLWCE 30 AGRELAALWR 40 VEARGRCEDS 50 AAARPFPTLT 60 MPGRNKAKST 70 CSCPDLQPNG 80 QDLGESGRVA 90 RLGADESEEE 100 GRRVPVSNAG 110 DPEIVKSPSD 120 PKQYRYIKLR 130 NGLQALLISD 140 LSNMEGKMGD 150 ATDDEEEEEE 160 EEEDDNDDDD 170 DDDDDEDSGA 180 EIEDDDEEGF 190 DDEDEFDDDD 200 DDEHDDDDDL 210 DTEDNELEEL 220 EERAEARKKT 230 TEKQQLQSLF 240 LLWSKLTDRL 250 WFKSTYTKMS 260 STLLVETRNL 270 YGVVGAESRS 280 VPVQHLAGWR 290 EEEQQGETDT 300 VLSAAALCVG 310 VGSFADPDDL 320 PGLAHFLEHM 330 VFMGSLKYPD 340 ENGFDAFLKK 350 HGGSDNASTD 360 CERTVFQFDV 370 QRKYFKEALD 380 RWAQFFIHPL 390 MIRDAIDREV 400 EAVDSEYQLA 410 RPSDANRKEM 420 LFGSLARPGH 430 PMGKFFWGNA 440 ETLKHEPKRN 450 NIDTHARLRE 460 FWMRFYSAHY 470 MTLVVQSKET 480 LDTLEKWVTE 490 IFSQIPNNGL 500 PKPNFGHLTD 510 PFDTPAFNKL 520 YRVVPIRKIH 530 ALTITWALPP 540 QQQHYRSKPL 550 HYISWLVGHE 560 GKGSILSYLR 570 KKCWALALFG 580 GNGETGFEQN 590 STYSVFSISI 600 TLTDEGYEHF 610 YEVAHTVFQY 620 LKMLQKLGPE 630 KRIFEEIQKI 640 EDNEFHYQEQ 650 TDPVEYVENM 660 CENMQLYPLQ 670 DFLTGDQLLF 680 EYKPEVIAEA 690 LNQLVPQKAN 700 LVLLSGANEG 710 KCDLKEKWFG 720 TQYSMEDIEN 730 SWAELWKSNF 740 ELNPDLHLPA 750 ENKYIATDFM 760 LKAFDCPETE 770 YPVKIVNTPQ 780 GCLWYKKDNK 790 FKIPKAYIRF 800 HLISPLIQKS 810 AANVVLFDIF 820 VNILTHNLAE 830 PAYEADVAQL 840 EYKLVAGEHG 850 LIIRVKGFNH 860 KLPLLFQLII 870 DYLAEFTSTP 880 AVFTMITEQL 890 KKTYFNILIK 900 PETLAKDVRL 910 LILEYARWSM 920 IDKYRALMDG 930 LSLESLLSFV 940 KEFKAQLFVE 950 GLVQGNVTST 960 ESTDFLKYVV 970 DKLNFMPLEQ 980 EMPVQFRVVE 990 LPGAHHLCKV 1000 RALNKGDANS 1010 EVTVYYQSGA 1020 RSLKEYTLME 1030 LLVMHMEEPC 1040 FDFLRTKQTL 1050 GYHVYPTCRN 1060 TSGILGFSVT 1070 VGTQATKYNS 1080 EVVDKKIEEF 1090 LSSFEEKIEN 1100 LTEDAFNTQV 1110 TALIKLKECE 1120 DTHLGEEVDR 1130 NWNEVVTQQY 1140 LFDRLAHEIE 1150 ALKSFSKSDL 1160 VSWFKAHRGP 1170 GSKMLSVHVV 1180 GFGKHELEED 1190 GIPSSEDSNS 1200 SCEVMQLTYL 1210 PASPLLADST 1220 IPITDIRAFT 1230 STLNLLPYHK IVK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0061133 endopeptidase activator activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004222 metalloendopeptidase activity
Biological Process GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.