Search Results
Overview
| Uniprot ID | A0A287AAA2 |
|---|---|
| Protein Name | Nardilysin |
| Gene Name | NRDC |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 989 | PGAHHLCKVRALNKG |
Function
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH)
Protein Sequence
10
MLRRVTVAAV
20
SATGRKLWCE
30
AGRELAALWR
40
VEARGRCEDS
50
AAARPFPTLT
60
MPGRNKAKST
70
CSCPDLQPNG
80
QDLGESGRVA
90
RLGADESEEE
100
GRRVPVSNAG
110
DPEIVKSPSD
120
PKQYRYIKLR
130
NGLQALLISD
140
LSNMEGKMGD
150
ATDDEEEEEE
160
EEEDDNDDDD
170
DDDDDEDSGA
180
EIEDDDEEGF
190
DDEDEFDDDD
200
DDEHDDDDDL
210
DTEDNELEEL
220
EERAEARKKT
230
TEKQQLQSLF
240
LLWSKLTDRL
250
WFKSTYTKMS
260
STLLVETRNL
270
YGVVGAESRS
280
VPVQHLAGWR
290
EEEQQGETDT
300
VLSAAALCVG
310
VGSFADPDDL
320
PGLAHFLEHM
330
VFMGSLKYPD
340
ENGFDAFLKK
350
HGGSDNASTD
360
CERTVFQFDV
370
QRKYFKEALD
380
RWAQFFIHPL
390
MIRDAIDREV
400
EAVDSEYQLA
410
RPSDANRKEM
420
LFGSLARPGH
430
PMGKFFWGNA
440
ETLKHEPKRN
450
NIDTHARLRE
460
FWMRFYSAHY
470
MTLVVQSKET
480
LDTLEKWVTE
490
IFSQIPNNGL
500
PKPNFGHLTD
510
PFDTPAFNKL
520
YRVVPIRKIH
530
ALTITWALPP
540
QQQHYRSKPL
550
HYISWLVGHE
560
GKGSILSYLR
570
KKCWALALFG
580
GNGETGFEQN
590
STYSVFSISI
600
TLTDEGYEHF
610
YEVAHTVFQY
620
LKMLQKLGPE
630
KRIFEEIQKI
640
EDNEFHYQEQ
650
TDPVEYVENM
660
CENMQLYPLQ
670
DFLTGDQLLF
680
EYKPEVIAEA
690
LNQLVPQKAN
700
LVLLSGANEG
710
KCDLKEKWFG
720
TQYSMEDIEN
730
SWAELWKSNF
740
ELNPDLHLPA
750
ENKYIATDFM
760
LKAFDCPETE
770
YPVKIVNTPQ
780
GCLWYKKDNK
790
FKIPKAYIRF
800
HLISPLIQKS
810
AANVVLFDIF
820
VNILTHNLAE
830
PAYEADVAQL
840
EYKLVAGEHG
850
LIIRVKGFNH
860
KLPLLFQLII
870
DYLAEFTSTP
880
AVFTMITEQL
890
KKTYFNILIK
900
PETLAKDVRL
910
LILEYARWSM
920
IDKYRALMDG
930
LSLESLLSFV
940
KEFKAQLFVE
950
GLVQGNVTST
960
ESTDFLKYVV
970
DKLNFMPLEQ
980
EMPVQFRVVE
990
LPGAHHLCKV
1000
RALNKGDANS
1010
EVTVYYQSGA
1020
RSLKEYTLME
1030
LLVMHMEEPC
1040
FDFLRTKQTL
1050
GYHVYPTCRN
1060
TSGILGFSVT
1070
VGTQATKYNS
1080
EVVDKKIEEF
1090
LSSFEEKIEN
1100
LTEDAFNTQV
1110
TALIKLKECE
1120
DTHLGEEVDR
1130
NWNEVVTQQY
1140
LFDRLAHEIE
1150
ALKSFSKSDL
1160
VSWFKAHRGP
1170
GSKMLSVHVV
1180
GFGKHELEED
1190
GIPSSEDSNS
1200
SCEVMQLTYL
1210
PASPLLADST
1220
IPITDIRAFT
1230
STLNLLPYHK
IVK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0061133 | endopeptidase activator activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004222 | metalloendopeptidase activity |
| Biological Process | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.