Overview
| Uniprot ID | A0A287AAB5 |
|---|
| Protein Name | High mobility group nucleosome-binding domain-containing protein 3 |
|---|
| Gene Name | HMGN3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
KDGSKVTKQEPTRRS |
Function
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function
Protein Sequence
10
MPKRKSPENT
20
EGKDGSKVTK
30
QEPTRRSARL
40
SAKPAPPKPE
50
PKPRKTSAKK
60
EPGTKMNKGA
70
KGKKEEKHEA
80
GKEGTAPSEN
90
GETKAEEIHI
100
SRSAVNVSAS
110
RGTPPSTLSV
120
KGQIETVRVK
GTEN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0031492 |
nucleosomal DNA binding |
| Biological Process |
GO:0006325 |
chromatin organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.