Overview
| Uniprot ID | A0A287AAK1 |
|---|
| Protein Name | COP9 signalosome complex subunit 1 |
|---|
| Gene Name | GPS1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 207 |
KALLKLEKLDTDLKN |
| 221 |
NYKGNSIKESIRRGH |
| 311 |
QTQAILTKLKCAAGL |
| 313 |
QAILTKLKCAAGLAE |
| 485 |
ARIDSHSKILYARDV |
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction
Protein Sequence
10
MPLPVQVFNL
20
QPASSVSGSG
30
GAESQDRMRG
40
GPAPRAAASS
50
VADVHCAPPS
60
GRSELFLPGT
70
AGDFSLSASL
80
SACTLLYEGA
90
VEPMQIDVDP
100
QEDPQNAPDV
110
NYVVENPTLD
120
LEQYAASYSG
130
LMRIERLQFI
140
ADHCPPLRAE
150
ALKMALSFVQ
160
RTFNVDMYEE
170
IHRKLSEATR
180
ELQNTPDAIP
190
ESGVEPPPLD
200
TAWVEATRKK
210
ALLKLEKLDT
220
DLKNYKGNSI
230
KESIRRGHDD
240
LGDHYLDCGD
250
LSNALKCYSR
260
ARDYCTSAKH
270
VINMCLNVIK
280
VSVYLQNWSH
290
VLSYVSKAES
300
TPEIAEQRGE
310
RDTQTQAILT
320
KLKCAAGLAE
330
LAARKYKQAA
340
KCFLLAAFDH
350
CDFPELLSPS
360
NVAVYGGLCA
370
LATFDRQELQ
380
RNVISSSSFK
390
LFLELEPQVR
400
DIIFKFYESK
410
YASCLKMLDE
420
MKDNLLLDMY
430
LAPHVRTLYT
440
QIRNRALIQY
450
FSPYVSADMR
460
KMATAFNTTV
470
AALEDELTQL
480
ILEGLINARI
490
DSHSKILYAR
500
DVDQRSTTFE
510
KSLLMGKEFQ
520
RRVKAMILRA
530
AVLRNQIHVK
540
SPPREGSQGE
550
LTPANSQSRM
STNM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.