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Overview

Uniprot IDA0A287AAV3
Protein NameSerine/arginine repetitive matrix protein 1
Gene NameSRRM1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
37 KFAECLEKKVDMSKV

Function

Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates

Protein Sequence

10 MQSGGYLMGT 20 SAEQDNRFSN 30 KQKKLLKQLK 40 FAECLEKKVD 50 MSKVNLEVIK 60 PWITKRVTEI 70 LGFEDDVVIE 80 FIFNQLEVKN 90 PDSKMMQINL 100 TGFLNGKNAR 110 EFMGELWPLL 120 LSAQENIAGI 130 PSAFLELKKE 140 EIKQRQIEQE 150 KLASMKKQDE 160 DKDKRDKEEK 170 ESSREKRERS 180 RSPRRRKSRS 190 PSPRRRSSPV 200 RRERKRSHSR 210 SPRHRTKSRS 220 PSPAPEKKEK 230 TPELPEPSVK 240 VKEPSVQEAT 250 STSDILKVPK 260 PEPVPEPKEP 270 SPEKNSKKEK 280 EKEKTRPRSR 290 SRSKSRSRTR 300 SRSPSHTRPR 310 RRHRSRSRSY 320 SPRRRPSPRR 330 RPSPRRRTPP 340 RRMPPPPRHR 350 RSRSPVRRRR 360 RSSASLSGSS 370 SSSSSSRSRS 380 PPKKAPKRTS 390 SPPRKTRRLS 400 PSASPPRRRH 410 RPSPPATPPP 420 KTRHSPTPQQ 430 SNRTRKSRVS 440 VSPGRTSGKV 450 TKHKGTEKRE 460 SPSPAPKPRK 470 VELSESDSGS 480 SSSSEDERPK 490 RSHVKNGEVG 500 RRRRHTPSRS 510 ASPSPRKRQK 520 ETSPRGRRRR 530 SPSPPPTRRR 540 RSPSPAPPPR 550 RRRSPTPPPR 560 RRTPSPPPRR 570 RSPSPRRYSP 580 PIQRRYSPSP 590 PPKRRTASPP 600 PPPKRRASPS 610 PPPKRRVSHS 620 PPPKQRSSPV 630 TKRRSPSLSS 640 KHRKGPSPSR 650 STREARSPQP 660 NKRHSPSPRP 670 RAPQTCSSPP 680 PARRGASSSP 690 QRRQSPSPSS 700 RPIRRVSRTP 710 EPKKTKKVAS 720 PSPQSVRRVS 730 SSRSVSGSPE 740 PAAKKPPAPP 750 SPVQSQSPST 760 NWSPAVPVKK 770 AKSPTPSPSP 780 ARNSDPEGGG 790 KKKKKKKDKK 800 HKKDKKHKKH 810 KKHKKEKAVA 820 AAAAAAVTPT 830 AIAAPTTTSA 840 QEEPEAEPEP 850 KKETESEAED 860 NLDDLEKHLR 870 EKALRSMRKA QVSPQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005681 spliceosomal complex
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.